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The impact of leg position on muscle blood flow and oxygenation during low-intensity rhythmic plantarflexion exercise

PURPOSE: Resistance training (RT) is an effective countermeasure to combat physical deconditioning whereby localized hypoxia within the limb increases metabolic stress eliciting muscle adaptation. The current study sought to examine the influence of gravity on muscle oxygenation (SmO(2)) alongside v...

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Autores principales: Marume, Kyohei, Mugele, Hendrik, Ueno, Ryo, Amin, Sachin B., Lesmana, Heru Syarli, Possnig, Carmen, Hansen, Alexander B., Simpson, Lydia L., Lawley, Justin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119266/
https://www.ncbi.nlm.nih.gov/pubmed/36645478
http://dx.doi.org/10.1007/s00421-022-05117-9
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author Marume, Kyohei
Mugele, Hendrik
Ueno, Ryo
Amin, Sachin B.
Lesmana, Heru Syarli
Possnig, Carmen
Hansen, Alexander B.
Simpson, Lydia L.
Lawley, Justin S.
author_facet Marume, Kyohei
Mugele, Hendrik
Ueno, Ryo
Amin, Sachin B.
Lesmana, Heru Syarli
Possnig, Carmen
Hansen, Alexander B.
Simpson, Lydia L.
Lawley, Justin S.
author_sort Marume, Kyohei
collection PubMed
description PURPOSE: Resistance training (RT) is an effective countermeasure to combat physical deconditioning whereby localized hypoxia within the limb increases metabolic stress eliciting muscle adaptation. The current study sought to examine the influence of gravity on muscle oxygenation (SmO(2)) alongside vascular hemodynamic responses. METHODS: In twelve young healthy adults, an ischemic occlusion test and seven minutes of low-intensity rhythmic plantarflexion exercise were used alongside superficial femoral blood flow and calf near-infrared spectroscopy to assess the microvascular vasodilator response, conduit artery flow-mediated dilation, exercise-induced hyperemia, and SmO(2) with the leg positioned above or below the heart in a randomized order. RESULTS: The microvascular vasodilator response, assessed by peak blood flow (798 ± 231 mL/min vs. 1348 ± 290 mL/min; p < 0.001) and reperfusion slope 10 s of SmO(2) after cuff deflation (0.75 ± 0.45%.s-1 vs.2.40 ± 0.94%.s-1; p < 0.001), was attenuated with the leg above the heart. This caused a blunted dilatation of the superficial femoral artery (3.0 ± 2.4% vs. 5.2 ± 2.1%; p = 0.008). Meanwhile, blood flow area under the curve was comparable (above the heart: 445 ± 147 mL vs. below the heart: 474 ± 118 mL; p = 0.55) in both leg positions. During rhythmic exercise, the increase in femoral blood flow was lower in the leg up position (above the heart: 201 ± 94% vs. below the heart: 292 ± 114%; p = 0.001) and contributed to a lower SmO(2) (above the heart: 41 ± 18% vs. below the heart 67 ± 5%; p < 0.001). CONCLUSION: Positioning the leg above the heart results in attenuated peak vascular dilator response and exercise-induced hyperemia that coincided with a lower SmO(2) during low-intensity plantarflexion exercise.
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spelling pubmed-101192662023-04-22 The impact of leg position on muscle blood flow and oxygenation during low-intensity rhythmic plantarflexion exercise Marume, Kyohei Mugele, Hendrik Ueno, Ryo Amin, Sachin B. Lesmana, Heru Syarli Possnig, Carmen Hansen, Alexander B. Simpson, Lydia L. Lawley, Justin S. Eur J Appl Physiol Original Article PURPOSE: Resistance training (RT) is an effective countermeasure to combat physical deconditioning whereby localized hypoxia within the limb increases metabolic stress eliciting muscle adaptation. The current study sought to examine the influence of gravity on muscle oxygenation (SmO(2)) alongside vascular hemodynamic responses. METHODS: In twelve young healthy adults, an ischemic occlusion test and seven minutes of low-intensity rhythmic plantarflexion exercise were used alongside superficial femoral blood flow and calf near-infrared spectroscopy to assess the microvascular vasodilator response, conduit artery flow-mediated dilation, exercise-induced hyperemia, and SmO(2) with the leg positioned above or below the heart in a randomized order. RESULTS: The microvascular vasodilator response, assessed by peak blood flow (798 ± 231 mL/min vs. 1348 ± 290 mL/min; p < 0.001) and reperfusion slope 10 s of SmO(2) after cuff deflation (0.75 ± 0.45%.s-1 vs.2.40 ± 0.94%.s-1; p < 0.001), was attenuated with the leg above the heart. This caused a blunted dilatation of the superficial femoral artery (3.0 ± 2.4% vs. 5.2 ± 2.1%; p = 0.008). Meanwhile, blood flow area under the curve was comparable (above the heart: 445 ± 147 mL vs. below the heart: 474 ± 118 mL; p = 0.55) in both leg positions. During rhythmic exercise, the increase in femoral blood flow was lower in the leg up position (above the heart: 201 ± 94% vs. below the heart: 292 ± 114%; p = 0.001) and contributed to a lower SmO(2) (above the heart: 41 ± 18% vs. below the heart 67 ± 5%; p < 0.001). CONCLUSION: Positioning the leg above the heart results in attenuated peak vascular dilator response and exercise-induced hyperemia that coincided with a lower SmO(2) during low-intensity plantarflexion exercise. Springer Berlin Heidelberg 2023-01-16 2023 /pmc/articles/PMC10119266/ /pubmed/36645478 http://dx.doi.org/10.1007/s00421-022-05117-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Marume, Kyohei
Mugele, Hendrik
Ueno, Ryo
Amin, Sachin B.
Lesmana, Heru Syarli
Possnig, Carmen
Hansen, Alexander B.
Simpson, Lydia L.
Lawley, Justin S.
The impact of leg position on muscle blood flow and oxygenation during low-intensity rhythmic plantarflexion exercise
title The impact of leg position on muscle blood flow and oxygenation during low-intensity rhythmic plantarflexion exercise
title_full The impact of leg position on muscle blood flow and oxygenation during low-intensity rhythmic plantarflexion exercise
title_fullStr The impact of leg position on muscle blood flow and oxygenation during low-intensity rhythmic plantarflexion exercise
title_full_unstemmed The impact of leg position on muscle blood flow and oxygenation during low-intensity rhythmic plantarflexion exercise
title_short The impact of leg position on muscle blood flow and oxygenation during low-intensity rhythmic plantarflexion exercise
title_sort impact of leg position on muscle blood flow and oxygenation during low-intensity rhythmic plantarflexion exercise
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119266/
https://www.ncbi.nlm.nih.gov/pubmed/36645478
http://dx.doi.org/10.1007/s00421-022-05117-9
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