Lack of correlation between hippocampal substructure atrophy and attention dysfunction in deficit schizophrenia

Hippocampal abnormalities are an established finding in the neuroimaging study of schizophrenia. However, no studies have examined the possibility of regional hippocampal abnormalities specific to deficit schizophrenia (DS) and associations with the unique symptoms of this schizophrenia subtype. Thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jin, Zhang, Xiaobin, Yang, Haidong, Yang, Man, Sun, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119300/
https://www.ncbi.nlm.nih.gov/pubmed/37080983
http://dx.doi.org/10.1038/s41537-023-00354-z
_version_ 1785028995795910656
author Li, Jin
Zhang, Xiaobin
Yang, Haidong
Yang, Man
Sun, Hongyan
author_facet Li, Jin
Zhang, Xiaobin
Yang, Haidong
Yang, Man
Sun, Hongyan
author_sort Li, Jin
collection PubMed
description Hippocampal abnormalities are an established finding in the neuroimaging study of schizophrenia. However, no studies have examined the possibility of regional hippocampal abnormalities specific to deficit schizophrenia (DS) and associations with the unique symptoms of this schizophrenia subtype. This study compared 33 DS and 39 non-deficit schizophrenia (NDS) patients and 38 healthy subjects for hippocampal subfield volumetry. Clinical symptoms were assessed by PANSS, cognition by the neurocognitive battery on the day of the MRI scan. The automatic hippocampal segmentation were preprocesses use FreeSurfer 7.2.0. Unfortunately, the associations between neurocognitive scores and hippocampal subfield volumes in the DS group were not significant after the Bonferroni correction. Our results did not support a causal relationship between hippocampal subregional atrophy and cognitive deficits in DS.
format Online
Article
Text
id pubmed-10119300
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-101193002023-04-22 Lack of correlation between hippocampal substructure atrophy and attention dysfunction in deficit schizophrenia Li, Jin Zhang, Xiaobin Yang, Haidong Yang, Man Sun, Hongyan Schizophrenia (Heidelb) Article Hippocampal abnormalities are an established finding in the neuroimaging study of schizophrenia. However, no studies have examined the possibility of regional hippocampal abnormalities specific to deficit schizophrenia (DS) and associations with the unique symptoms of this schizophrenia subtype. This study compared 33 DS and 39 non-deficit schizophrenia (NDS) patients and 38 healthy subjects for hippocampal subfield volumetry. Clinical symptoms were assessed by PANSS, cognition by the neurocognitive battery on the day of the MRI scan. The automatic hippocampal segmentation were preprocesses use FreeSurfer 7.2.0. Unfortunately, the associations between neurocognitive scores and hippocampal subfield volumes in the DS group were not significant after the Bonferroni correction. Our results did not support a causal relationship between hippocampal subregional atrophy and cognitive deficits in DS. Nature Publishing Group UK 2023-04-20 /pmc/articles/PMC10119300/ /pubmed/37080983 http://dx.doi.org/10.1038/s41537-023-00354-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Li, Jin
Zhang, Xiaobin
Yang, Haidong
Yang, Man
Sun, Hongyan
Lack of correlation between hippocampal substructure atrophy and attention dysfunction in deficit schizophrenia
title Lack of correlation between hippocampal substructure atrophy and attention dysfunction in deficit schizophrenia
title_full Lack of correlation between hippocampal substructure atrophy and attention dysfunction in deficit schizophrenia
title_fullStr Lack of correlation between hippocampal substructure atrophy and attention dysfunction in deficit schizophrenia
title_full_unstemmed Lack of correlation between hippocampal substructure atrophy and attention dysfunction in deficit schizophrenia
title_short Lack of correlation between hippocampal substructure atrophy and attention dysfunction in deficit schizophrenia
title_sort lack of correlation between hippocampal substructure atrophy and attention dysfunction in deficit schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119300/
https://www.ncbi.nlm.nih.gov/pubmed/37080983
http://dx.doi.org/10.1038/s41537-023-00354-z
work_keys_str_mv AT lijin lackofcorrelationbetweenhippocampalsubstructureatrophyandattentiondysfunctionindeficitschizophrenia
AT zhangxiaobin lackofcorrelationbetweenhippocampalsubstructureatrophyandattentiondysfunctionindeficitschizophrenia
AT yanghaidong lackofcorrelationbetweenhippocampalsubstructureatrophyandattentiondysfunctionindeficitschizophrenia
AT yangman lackofcorrelationbetweenhippocampalsubstructureatrophyandattentiondysfunctionindeficitschizophrenia
AT sunhongyan lackofcorrelationbetweenhippocampalsubstructureatrophyandattentiondysfunctionindeficitschizophrenia

Ejemplares similares