The therapeutic potential of neurofibromin signaling pathways and binding partners

Neurofibromin controls many cell processes, such as growth, learning, and memory. If neurofibromin is not working properly, it can lead to health problems, including issues with the nervous, skeletal, and cardiovascular systems and cancer. This review examines neurofibromin’s binding partners, signa...

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Autores principales: Báez-Flores, Juan, Rodríguez-Martín, Mario, Lacal, Jesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119308/
https://www.ncbi.nlm.nih.gov/pubmed/37081086
http://dx.doi.org/10.1038/s42003-023-04815-0
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author Báez-Flores, Juan
Rodríguez-Martín, Mario
Lacal, Jesus
author_facet Báez-Flores, Juan
Rodríguez-Martín, Mario
Lacal, Jesus
author_sort Báez-Flores, Juan
collection PubMed
description Neurofibromin controls many cell processes, such as growth, learning, and memory. If neurofibromin is not working properly, it can lead to health problems, including issues with the nervous, skeletal, and cardiovascular systems and cancer. This review examines neurofibromin’s binding partners, signaling pathways and potential therapeutic targets. In addition, it summarizes the different post-translational modifications that can affect neurofibromin’s interactions with other molecules. It is essential to investigate the molecular mechanisms that underlie neurofibromin variants in order to provide with functional connections between neurofibromin and its associated proteins for possible therapeutic targets based on its biological function.
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spelling pubmed-101193082023-04-22 The therapeutic potential of neurofibromin signaling pathways and binding partners Báez-Flores, Juan Rodríguez-Martín, Mario Lacal, Jesus Commun Biol Review Article Neurofibromin controls many cell processes, such as growth, learning, and memory. If neurofibromin is not working properly, it can lead to health problems, including issues with the nervous, skeletal, and cardiovascular systems and cancer. This review examines neurofibromin’s binding partners, signaling pathways and potential therapeutic targets. In addition, it summarizes the different post-translational modifications that can affect neurofibromin’s interactions with other molecules. It is essential to investigate the molecular mechanisms that underlie neurofibromin variants in order to provide with functional connections between neurofibromin and its associated proteins for possible therapeutic targets based on its biological function. Nature Publishing Group UK 2023-04-20 /pmc/articles/PMC10119308/ /pubmed/37081086 http://dx.doi.org/10.1038/s42003-023-04815-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Báez-Flores, Juan
Rodríguez-Martín, Mario
Lacal, Jesus
The therapeutic potential of neurofibromin signaling pathways and binding partners
title The therapeutic potential of neurofibromin signaling pathways and binding partners
title_full The therapeutic potential of neurofibromin signaling pathways and binding partners
title_fullStr The therapeutic potential of neurofibromin signaling pathways and binding partners
title_full_unstemmed The therapeutic potential of neurofibromin signaling pathways and binding partners
title_short The therapeutic potential of neurofibromin signaling pathways and binding partners
title_sort therapeutic potential of neurofibromin signaling pathways and binding partners
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119308/
https://www.ncbi.nlm.nih.gov/pubmed/37081086
http://dx.doi.org/10.1038/s42003-023-04815-0
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