Cargando…

Distinctive Effects of D1 and D2 Receptor Agonists on Cortico-Basal Ganglia Oscillations in a Rodent Model of L-DOPA-Induced Dyskinesia

L-DOPA-induced dyskinesia (LID) in Parkinson’s disease has been linked to oscillatory neuronal activities in the cortico-basal ganglia network. We set out to examine the pattern of cortico-basal ganglia oscillations induced by selective agonists of D1 and D2 receptors in a rat model of LID. Local fi...

Descripción completa

Detalles Bibliográficos
Autores principales: Skovgård, Katrine, Barrientos, Sebastian A., Petersson, Per, Halje, Pär, Cenci, M. Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119363/
https://www.ncbi.nlm.nih.gov/pubmed/36344723
http://dx.doi.org/10.1007/s13311-022-01309-5
_version_ 1785029006297399296
author Skovgård, Katrine
Barrientos, Sebastian A.
Petersson, Per
Halje, Pär
Cenci, M. Angela
author_facet Skovgård, Katrine
Barrientos, Sebastian A.
Petersson, Per
Halje, Pär
Cenci, M. Angela
author_sort Skovgård, Katrine
collection PubMed
description L-DOPA-induced dyskinesia (LID) in Parkinson’s disease has been linked to oscillatory neuronal activities in the cortico-basal ganglia network. We set out to examine the pattern of cortico-basal ganglia oscillations induced by selective agonists of D1 and D2 receptors in a rat model of LID. Local field potentials were recorded in freely moving rats using large-scale electrodes targeting three motor cortical regions, dorsomedial and dorsolateral striatum, external globus pallidus, and substantial nigra pars reticulata. Abnormal involuntary movements were elicited by the D1 agonist SKF82958 or the D2 agonist sumanirole, while overall motor activity was quantified using video analysis (DeepLabCut). Both SKF82958 and sumanirole induced dyskinesia, although with significant differences in temporal course, overall severity, and body distribution. The D1 agonist induced prominent narrowband oscillations in the high gamma range (70–110 Hz) in all recorded structures except for the nigra reticulata. Additionally, the D1 agonist induced strong functional connectivity between the recorded structures and the phase analysis revealed that the primary motor cortex (forelimb area) was leading a supplementary motor area and striatum. Following treatment with the D2 agonist, narrowband gamma oscillations were detected only in forelimb motor cortex and dorsolateral striatum, while prominent oscillations in the theta band occurred in the globus pallidus and nigra reticulata. Our results reveal that the dyskinetic effects of D1 and D2 receptor agonists are associated with distinct patterns of cortico-basal ganglia oscillations, suggesting a recruitment of partially distinct networks. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13311-022-01309-5.
format Online
Article
Text
id pubmed-10119363
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-101193632023-04-22 Distinctive Effects of D1 and D2 Receptor Agonists on Cortico-Basal Ganglia Oscillations in a Rodent Model of L-DOPA-Induced Dyskinesia Skovgård, Katrine Barrientos, Sebastian A. Petersson, Per Halje, Pär Cenci, M. Angela Neurotherapeutics Original Article L-DOPA-induced dyskinesia (LID) in Parkinson’s disease has been linked to oscillatory neuronal activities in the cortico-basal ganglia network. We set out to examine the pattern of cortico-basal ganglia oscillations induced by selective agonists of D1 and D2 receptors in a rat model of LID. Local field potentials were recorded in freely moving rats using large-scale electrodes targeting three motor cortical regions, dorsomedial and dorsolateral striatum, external globus pallidus, and substantial nigra pars reticulata. Abnormal involuntary movements were elicited by the D1 agonist SKF82958 or the D2 agonist sumanirole, while overall motor activity was quantified using video analysis (DeepLabCut). Both SKF82958 and sumanirole induced dyskinesia, although with significant differences in temporal course, overall severity, and body distribution. The D1 agonist induced prominent narrowband oscillations in the high gamma range (70–110 Hz) in all recorded structures except for the nigra reticulata. Additionally, the D1 agonist induced strong functional connectivity between the recorded structures and the phase analysis revealed that the primary motor cortex (forelimb area) was leading a supplementary motor area and striatum. Following treatment with the D2 agonist, narrowband gamma oscillations were detected only in forelimb motor cortex and dorsolateral striatum, while prominent oscillations in the theta band occurred in the globus pallidus and nigra reticulata. Our results reveal that the dyskinetic effects of D1 and D2 receptor agonists are associated with distinct patterns of cortico-basal ganglia oscillations, suggesting a recruitment of partially distinct networks. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13311-022-01309-5. Springer International Publishing 2022-11-07 2023-01 /pmc/articles/PMC10119363/ /pubmed/36344723 http://dx.doi.org/10.1007/s13311-022-01309-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Skovgård, Katrine
Barrientos, Sebastian A.
Petersson, Per
Halje, Pär
Cenci, M. Angela
Distinctive Effects of D1 and D2 Receptor Agonists on Cortico-Basal Ganglia Oscillations in a Rodent Model of L-DOPA-Induced Dyskinesia
title Distinctive Effects of D1 and D2 Receptor Agonists on Cortico-Basal Ganglia Oscillations in a Rodent Model of L-DOPA-Induced Dyskinesia
title_full Distinctive Effects of D1 and D2 Receptor Agonists on Cortico-Basal Ganglia Oscillations in a Rodent Model of L-DOPA-Induced Dyskinesia
title_fullStr Distinctive Effects of D1 and D2 Receptor Agonists on Cortico-Basal Ganglia Oscillations in a Rodent Model of L-DOPA-Induced Dyskinesia
title_full_unstemmed Distinctive Effects of D1 and D2 Receptor Agonists on Cortico-Basal Ganglia Oscillations in a Rodent Model of L-DOPA-Induced Dyskinesia
title_short Distinctive Effects of D1 and D2 Receptor Agonists on Cortico-Basal Ganglia Oscillations in a Rodent Model of L-DOPA-Induced Dyskinesia
title_sort distinctive effects of d1 and d2 receptor agonists on cortico-basal ganglia oscillations in a rodent model of l-dopa-induced dyskinesia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119363/
https://www.ncbi.nlm.nih.gov/pubmed/36344723
http://dx.doi.org/10.1007/s13311-022-01309-5
work_keys_str_mv AT skovgardkatrine distinctiveeffectsofd1andd2receptoragonistsoncorticobasalgangliaoscillationsinarodentmodelofldopainduceddyskinesia
AT barrientossebastiana distinctiveeffectsofd1andd2receptoragonistsoncorticobasalgangliaoscillationsinarodentmodelofldopainduceddyskinesia
AT peterssonper distinctiveeffectsofd1andd2receptoragonistsoncorticobasalgangliaoscillationsinarodentmodelofldopainduceddyskinesia
AT haljepar distinctiveeffectsofd1andd2receptoragonistsoncorticobasalgangliaoscillationsinarodentmodelofldopainduceddyskinesia
AT cencimangela distinctiveeffectsofd1andd2receptoragonistsoncorticobasalgangliaoscillationsinarodentmodelofldopainduceddyskinesia