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Quaternized Chitosan Derivatives as Viable Antiviral Agents: Structure–Activity Correlations and Mechanisms of Action
[Image: see text] Cationic polysaccharides have demonstrated significant antimicrobial properties and have great potential in medical applications, where the antiviral activity is of great interest. As of today, alcohols and oxidizing agents are commonly used as antiviral disinfectants. However, the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119858/ https://www.ncbi.nlm.nih.gov/pubmed/37014147 http://dx.doi.org/10.1021/acsami.3c01421 |
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author | Teotia, Arun Laurén, Isabella Borandeh, Sedigheh Seppälä, Jukka |
author_facet | Teotia, Arun Laurén, Isabella Borandeh, Sedigheh Seppälä, Jukka |
author_sort | Teotia, Arun |
collection | PubMed |
description | [Image: see text] Cationic polysaccharides have demonstrated significant antimicrobial properties and have great potential in medical applications, where the antiviral activity is of great interest. As of today, alcohols and oxidizing agents are commonly used as antiviral disinfectants. However, these compounds are not environmentally safe, have short activity periods, and may cause health issues. Therefore, this study aimed to develop metal-free and environmentally friendly quaternary chitosans (QCs) with excellent long-lasting virucidal activity. To evaluate this, both single and double QCs were obtained using AETMAC ([2-(acryloyloxy)ethyl]-trimethylammonium chloride) and GTMAC (glycidyl trimethylammonium chloride) quaternary precursors. Further, this study investigated the influence of the quaternary functional group, charge density, and molecular weight (M(w)) on the antiviral properties of QCs. It is proposed that the higher charge density, along with the length of alkyl linkers, and hydrophobic interactions affected the antiviral activity of QCs. The findings demonstrated that heterogeneously functionalized chitosan exhibited excellent antiviral activity against both the enveloped virus φ6 and the nonenveloped viruses φX174 and MS2. These quaternized chitosan derivatives have promising potential as viable antiviral agents, as hand/surface sanitizers, or in other biomedical applications. |
format | Online Article Text |
id | pubmed-10119858 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-101198582023-04-22 Quaternized Chitosan Derivatives as Viable Antiviral Agents: Structure–Activity Correlations and Mechanisms of Action Teotia, Arun Laurén, Isabella Borandeh, Sedigheh Seppälä, Jukka ACS Appl Mater Interfaces [Image: see text] Cationic polysaccharides have demonstrated significant antimicrobial properties and have great potential in medical applications, where the antiviral activity is of great interest. As of today, alcohols and oxidizing agents are commonly used as antiviral disinfectants. However, these compounds are not environmentally safe, have short activity periods, and may cause health issues. Therefore, this study aimed to develop metal-free and environmentally friendly quaternary chitosans (QCs) with excellent long-lasting virucidal activity. To evaluate this, both single and double QCs were obtained using AETMAC ([2-(acryloyloxy)ethyl]-trimethylammonium chloride) and GTMAC (glycidyl trimethylammonium chloride) quaternary precursors. Further, this study investigated the influence of the quaternary functional group, charge density, and molecular weight (M(w)) on the antiviral properties of QCs. It is proposed that the higher charge density, along with the length of alkyl linkers, and hydrophobic interactions affected the antiviral activity of QCs. The findings demonstrated that heterogeneously functionalized chitosan exhibited excellent antiviral activity against both the enveloped virus φ6 and the nonenveloped viruses φX174 and MS2. These quaternized chitosan derivatives have promising potential as viable antiviral agents, as hand/surface sanitizers, or in other biomedical applications. American Chemical Society 2023-04-04 /pmc/articles/PMC10119858/ /pubmed/37014147 http://dx.doi.org/10.1021/acsami.3c01421 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Teotia, Arun Laurén, Isabella Borandeh, Sedigheh Seppälä, Jukka Quaternized Chitosan Derivatives as Viable Antiviral Agents: Structure–Activity Correlations and Mechanisms of Action |
title | Quaternized Chitosan
Derivatives as Viable Antiviral
Agents: Structure–Activity Correlations and Mechanisms of Action |
title_full | Quaternized Chitosan
Derivatives as Viable Antiviral
Agents: Structure–Activity Correlations and Mechanisms of Action |
title_fullStr | Quaternized Chitosan
Derivatives as Viable Antiviral
Agents: Structure–Activity Correlations and Mechanisms of Action |
title_full_unstemmed | Quaternized Chitosan
Derivatives as Viable Antiviral
Agents: Structure–Activity Correlations and Mechanisms of Action |
title_short | Quaternized Chitosan
Derivatives as Viable Antiviral
Agents: Structure–Activity Correlations and Mechanisms of Action |
title_sort | quaternized chitosan
derivatives as viable antiviral
agents: structure–activity correlations and mechanisms of action |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119858/ https://www.ncbi.nlm.nih.gov/pubmed/37014147 http://dx.doi.org/10.1021/acsami.3c01421 |
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