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Molecular Mechanisms of Amyloid-β Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone

[Image: see text] Self-replication of amyloid-β-peptide (Aβ) fibril formation is a hallmark in Alzheimer’s disease (AD). Detailed insights have been obtained in Aβ self-assembly in vitro, yet whether similar mechanisms are relevant in vivo has remained elusive. Here, we investigated the ability of i...

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Detalles Bibliográficos
Autores principales:	Kumar, Rakesh, Arroyo-García, Luis Enrique, Manchanda, Shaffi, Adam, Laurène, Pizzirusso, Giusy, Biverstål, Henrik, Nilsson, Per, Fisahn, André, Johansson, Jan, Abelein, Axel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119923/ https://www.ncbi.nlm.nih.gov/pubmed/37023330 http://dx.doi.org/10.1021/acschemneuro.3c00044

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