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Synthesis and Antagonist Activity of Methyllycaconitine Analogues on Human α7 Nicotinic Acetylcholine Receptors

[Image: see text] Methyllycaconitine (MLA), 1, is a naturally occurring norditerpenoid alkaloid that is a highly potent (IC(50) = 2 nM) selective antagonist of α7 nicotinic acetylcholine receptors (nAChRs). Several structural factors affect its activity such as the neopentyl ester side-chain and the...

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Detalles Bibliográficos
Autores principales:	Qasem, Ashraf M. A., Rowan, Michael G., Sanders, Victoria R., Millar, Neil S., Blagbrough, Ian S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119942/ https://www.ncbi.nlm.nih.gov/pubmed/37096031 http://dx.doi.org/10.1021/acsbiomedchemau.2c00057

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