Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by (19)F NMR and Cryo-EM

[Image: see text] Limited chemical shift dispersion represents a significant barrier to studying multistate equilibria of large membrane proteins by (19)F NMR. We describe a novel monofluoroethyl (19)F probe that dramatically increases the chemical shift dispersion. The improved conformational sensi...

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Detalles Bibliográficos
Autores principales: Huang, Yun, Reddy, Krishna D., Bracken, Clay, Qiu, Biao, Zhan, Wenhu, Eliezer, David, Boudker, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119980/
https://www.ncbi.nlm.nih.gov/pubmed/37023263
http://dx.doi.org/10.1021/jacs.3c01003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119980/
https://www.ncbi.nlm.nih.gov/pubmed/37023263
http://dx.doi.org/10.1021/jacs.3c01003

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