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Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by (19)F NMR and Cryo-EM

[Image: see text] Limited chemical shift dispersion represents a significant barrier to studying multistate equilibria of large membrane proteins by (19)F NMR. We describe a novel monofluoroethyl (19)F probe that dramatically increases the chemical shift dispersion. The improved conformational sensi...

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Detalles Bibliográficos
Autores principales:	Huang, Yun, Reddy, Krishna D., Bracken, Clay, Qiu, Biao, Zhan, Wenhu, Eliezer, David, Boudker, Olga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119980/ https://www.ncbi.nlm.nih.gov/pubmed/37023263 http://dx.doi.org/10.1021/jacs.3c01003

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