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Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) possess mutations that confer resistance to neutralizing antibodies within the Spike protein and are associated with breakthrough infection and reinfection. By contrast, less is known about the escape from CD8+ T...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120007/ https://www.ncbi.nlm.nih.gov/pubmed/37036977 http://dx.doi.org/10.1073/pnas.2221652120 |
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author | Moriyama, Miyu Lucas, Carolina Monteiro, Valter Silva Iwasaki, Akiko |
author_facet | Moriyama, Miyu Lucas, Carolina Monteiro, Valter Silva Iwasaki, Akiko |
author_sort | Moriyama, Miyu |
collection | PubMed |
description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) possess mutations that confer resistance to neutralizing antibodies within the Spike protein and are associated with breakthrough infection and reinfection. By contrast, less is known about the escape from CD8+ T cell-mediated immunity by VOC. Here, we demonstrated that all SARS-CoV-2 VOCs possess the ability to suppress major histocompatibility complex class I (MHC-I) expression. We identified several viral genes that contribute to the suppression of MHC I expression. Notably, MHC-I upregulation was strongly inhibited after SARS-CoV-2 but not influenza virus infection in vivo. While earlier VOCs possess similar capacity as the ancestral strain to suppress MHC-I, the Omicron subvariants exhibited a greater ability to suppress surface MHC-I expression. We identified a common mutation in the E protein of Omicron that further suppressed MHC-I expression. Collectively, our data suggest that in addition to escaping from neutralizing antibodies, the success of Omicron subvariants to cause breakthrough infection and reinfection may in part be due to its optimized evasion from T cell recognition. |
format | Online Article Text |
id | pubmed-10120007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-101200072023-04-22 Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants Moriyama, Miyu Lucas, Carolina Monteiro, Valter Silva Iwasaki, Akiko Proc Natl Acad Sci U S A Biological Sciences Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) possess mutations that confer resistance to neutralizing antibodies within the Spike protein and are associated with breakthrough infection and reinfection. By contrast, less is known about the escape from CD8+ T cell-mediated immunity by VOC. Here, we demonstrated that all SARS-CoV-2 VOCs possess the ability to suppress major histocompatibility complex class I (MHC-I) expression. We identified several viral genes that contribute to the suppression of MHC I expression. Notably, MHC-I upregulation was strongly inhibited after SARS-CoV-2 but not influenza virus infection in vivo. While earlier VOCs possess similar capacity as the ancestral strain to suppress MHC-I, the Omicron subvariants exhibited a greater ability to suppress surface MHC-I expression. We identified a common mutation in the E protein of Omicron that further suppressed MHC-I expression. Collectively, our data suggest that in addition to escaping from neutralizing antibodies, the success of Omicron subvariants to cause breakthrough infection and reinfection may in part be due to its optimized evasion from T cell recognition. National Academy of Sciences 2023-04-10 2023-04-18 /pmc/articles/PMC10120007/ /pubmed/37036977 http://dx.doi.org/10.1073/pnas.2221652120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Biological Sciences Moriyama, Miyu Lucas, Carolina Monteiro, Valter Silva Iwasaki, Akiko Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants |
title | Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants |
title_full | Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants |
title_fullStr | Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants |
title_full_unstemmed | Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants |
title_short | Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants |
title_sort | enhanced inhibition of mhc-i expression by sars-cov-2 omicron subvariants |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120007/ https://www.ncbi.nlm.nih.gov/pubmed/37036977 http://dx.doi.org/10.1073/pnas.2221652120 |
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