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Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens

Bromo- and extra-terminal domain inhibitors (BETi) have exhibited therapeutic activities in many cancers. However, the mechanisms controlling BETi response and resistance are not well understood. We conducted genome-wide loss-of-function CRISPR screens using BETi-treated KMT2A-rearranged (KMT2A-r) c...

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Detalles Bibliográficos
Autores principales:	Wright, Shaela, Hu, Jianzhong, Wang, Hong, Hyle, Judith, Zhang, Yang, Du, Guoqing, Konopleva, Marina Y., Kornblau, Steven M., Djekidel, Mohamed Nadhir, Rosikiewicz, Wojciech, Xu, Beisi, Lu, Rui, Yang, Jun J., Li, Chunliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120025/ https://www.ncbi.nlm.nih.gov/pubmed/37036970 http://dx.doi.org/10.1073/pnas.2220134120

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