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B cell peripheral tolerance is promoted by cathepsin B protease

B cells that bind soluble autoantigens receive chronic signaling via the B cell receptor (signal-1) in the absence of strong costimulatory signals (signal-2), and this leads to their elimination in peripheral tissues. The factors determining the extent of soluble autoantigen-binding B cell eliminati...

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Detalles Bibliográficos
Autores principales: Chou, Marissa Y., Liu, Dan, An, Jinping, Xu, Ying, Cyster, Jason G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120085/
https://www.ncbi.nlm.nih.gov/pubmed/37040412
http://dx.doi.org/10.1073/pnas.2300099120