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B cell peripheral tolerance is promoted by cathepsin B protease
B cells that bind soluble autoantigens receive chronic signaling via the B cell receptor (signal-1) in the absence of strong costimulatory signals (signal-2), and this leads to their elimination in peripheral tissues. The factors determining the extent of soluble autoantigen-binding B cell eliminati...
Autores principales: | Chou, Marissa Y., Liu, Dan, An, Jinping, Xu, Ying, Cyster, Jason G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120085/ https://www.ncbi.nlm.nih.gov/pubmed/37040412 http://dx.doi.org/10.1073/pnas.2300099120 |
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