CasKAS: direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping

Detecting and mitigating off-target activity is critical to the practical application of CRISPR-mediated genome and epigenome editing. While numerous methods have been developed to map Cas9 binding specificity genome-wide, they are generally time-consuming and/or expensive, and not applicable to cat...

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Detalles Bibliográficos
Autores principales: Marinov, Georgi K., Kim, Samuel H., Bagdatli, S. Tansu, Higashino, Soon Il, Trevino, Alexandro E., Tycko, Josh, Wu, Tong, Bintu, Lacramioara, Bassik, Michael C., He, Chuan, Kundaje, Anshul, Greenleaf, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120127/
https://www.ncbi.nlm.nih.gov/pubmed/37085898
http://dx.doi.org/10.1186/s13059-023-02930-z

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