A rare case of primary gastric Hodgkin lymphoma in an adolescent with Nijmegen breakage syndrome

BACKGROUND: Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive DNA repair disorder that increases risk of hematological malignancy. Primary gastric malignancies are exceedingly rare in pediatric patients and not typically high on the differential of abdominal pain. CASE PRESENTATION: A 1...

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Autores principales: Batiuk, Elizabeth, Bassett, Mikelle, Hakar, Melanie, Lin, Henry C., Hunter, Anna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120165/
https://www.ncbi.nlm.nih.gov/pubmed/37085783
http://dx.doi.org/10.1186/s12887-023-03929-y
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author Batiuk, Elizabeth
Bassett, Mikelle
Hakar, Melanie
Lin, Henry C.
Hunter, Anna K.
author_facet Batiuk, Elizabeth
Bassett, Mikelle
Hakar, Melanie
Lin, Henry C.
Hunter, Anna K.
author_sort Batiuk, Elizabeth
collection PubMed
description BACKGROUND: Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive DNA repair disorder that increases risk of hematological malignancy. Primary gastric malignancies are exceedingly rare in pediatric patients and not typically high on the differential of abdominal pain. CASE PRESENTATION: A 14-year-old male with NBS presented with persistent abdominal pain and was diagnosed with primary Hodgkin disease of the stomach. CONCLUSIONS: In pediatric patients with predisposition to malignancies, such as those with underlying chromosome instability disorders, all symptoms must be carefully considered.
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spelling pubmed-101201652023-04-22 A rare case of primary gastric Hodgkin lymphoma in an adolescent with Nijmegen breakage syndrome Batiuk, Elizabeth Bassett, Mikelle Hakar, Melanie Lin, Henry C. Hunter, Anna K. BMC Pediatr Case Report BACKGROUND: Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive DNA repair disorder that increases risk of hematological malignancy. Primary gastric malignancies are exceedingly rare in pediatric patients and not typically high on the differential of abdominal pain. CASE PRESENTATION: A 14-year-old male with NBS presented with persistent abdominal pain and was diagnosed with primary Hodgkin disease of the stomach. CONCLUSIONS: In pediatric patients with predisposition to malignancies, such as those with underlying chromosome instability disorders, all symptoms must be carefully considered. BioMed Central 2023-04-21 /pmc/articles/PMC10120165/ /pubmed/37085783 http://dx.doi.org/10.1186/s12887-023-03929-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Batiuk, Elizabeth
Bassett, Mikelle
Hakar, Melanie
Lin, Henry C.
Hunter, Anna K.
A rare case of primary gastric Hodgkin lymphoma in an adolescent with Nijmegen breakage syndrome
title A rare case of primary gastric Hodgkin lymphoma in an adolescent with Nijmegen breakage syndrome
title_full A rare case of primary gastric Hodgkin lymphoma in an adolescent with Nijmegen breakage syndrome
title_fullStr A rare case of primary gastric Hodgkin lymphoma in an adolescent with Nijmegen breakage syndrome
title_full_unstemmed A rare case of primary gastric Hodgkin lymphoma in an adolescent with Nijmegen breakage syndrome
title_short A rare case of primary gastric Hodgkin lymphoma in an adolescent with Nijmegen breakage syndrome
title_sort rare case of primary gastric hodgkin lymphoma in an adolescent with nijmegen breakage syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120165/
https://www.ncbi.nlm.nih.gov/pubmed/37085783
http://dx.doi.org/10.1186/s12887-023-03929-y
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