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NAD(+)-dependent mechanism of pathological axon degeneration

Pathological axon degeneration is broadly observed in neurodegenerative diseases. This unique process of axonal pathology could directly interfere with the normal functions of neurocircuitries and contribute to the onset of clinical symptoms in patients. It has been increasingly recognized that func...

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Detalles Bibliográficos
Autores principales: Cao, Ying, Wang, Yi, Yang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120281/
https://www.ncbi.nlm.nih.gov/pubmed/37193131
http://dx.doi.org/10.1016/j.cellin.2022.100019
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author Cao, Ying
Wang, Yi
Yang, Jing
author_facet Cao, Ying
Wang, Yi
Yang, Jing
author_sort Cao, Ying
collection PubMed
description Pathological axon degeneration is broadly observed in neurodegenerative diseases. This unique process of axonal pathology could directly interfere with the normal functions of neurocircuitries and contribute to the onset of clinical symptoms in patients. It has been increasingly recognized that functional preservation of axonal structures is an indispensable part of therapeutic strategies for treating neurological disorders. In the past decades, the research field has witnessed significant breakthroughs in understanding the stereotyped self-destruction of axons upon neurodegenerative insults, which is distinct from all the known types of programmed cell death. In particular, the novel NAD(+)-dependent mechanism involving the WLD(s), NMNAT2, and SARM1 proteins has emerged. This review summarizes the landmark discoveries elucidating the molecular pathway of pathological axon degeneration and highlights the evolving concept that neurodegeneration would be intrinsically linked to NAD(+) and energy metabolism.
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spelling pubmed-101202812023-05-15 NAD(+)-dependent mechanism of pathological axon degeneration Cao, Ying Wang, Yi Yang, Jing Cell Insight Review Pathological axon degeneration is broadly observed in neurodegenerative diseases. This unique process of axonal pathology could directly interfere with the normal functions of neurocircuitries and contribute to the onset of clinical symptoms in patients. It has been increasingly recognized that functional preservation of axonal structures is an indispensable part of therapeutic strategies for treating neurological disorders. In the past decades, the research field has witnessed significant breakthroughs in understanding the stereotyped self-destruction of axons upon neurodegenerative insults, which is distinct from all the known types of programmed cell death. In particular, the novel NAD(+)-dependent mechanism involving the WLD(s), NMNAT2, and SARM1 proteins has emerged. This review summarizes the landmark discoveries elucidating the molecular pathway of pathological axon degeneration and highlights the evolving concept that neurodegeneration would be intrinsically linked to NAD(+) and energy metabolism. Elsevier 2022-03-04 /pmc/articles/PMC10120281/ /pubmed/37193131 http://dx.doi.org/10.1016/j.cellin.2022.100019 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Cao, Ying
Wang, Yi
Yang, Jing
NAD(+)-dependent mechanism of pathological axon degeneration
title NAD(+)-dependent mechanism of pathological axon degeneration
title_full NAD(+)-dependent mechanism of pathological axon degeneration
title_fullStr NAD(+)-dependent mechanism of pathological axon degeneration
title_full_unstemmed NAD(+)-dependent mechanism of pathological axon degeneration
title_short NAD(+)-dependent mechanism of pathological axon degeneration
title_sort nad(+)-dependent mechanism of pathological axon degeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120281/
https://www.ncbi.nlm.nih.gov/pubmed/37193131
http://dx.doi.org/10.1016/j.cellin.2022.100019
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