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The role of TRPA1 channels in thermosensation
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal nonselective cation channel sensitive to different physical and chemical stimuli. TRPA1 is associated with many important physiological functions in different species and thus is involved in different degrees of evolution. TRPA1 acts as a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120293/ https://www.ncbi.nlm.nih.gov/pubmed/37193355 http://dx.doi.org/10.1016/j.cellin.2022.100059 |
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author | Zhang, Hao Wang, Chengsan Zhang, Keyi Kamau, Peter Muiruri Luo, Anna Tian, Lifeng Lai, Ren |
author_facet | Zhang, Hao Wang, Chengsan Zhang, Keyi Kamau, Peter Muiruri Luo, Anna Tian, Lifeng Lai, Ren |
author_sort | Zhang, Hao |
collection | PubMed |
description | Transient receptor potential ankyrin 1 (TRPA1) is a polymodal nonselective cation channel sensitive to different physical and chemical stimuli. TRPA1 is associated with many important physiological functions in different species and thus is involved in different degrees of evolution. TRPA1 acts as a polymodal receptor for the perceiving of irritating chemicals, cold, heat, and mechanical sensations in various animal species. Numerous studies have supported many functions of TRPA1, but its temperature-sensing function remains controversial. Although TRPA1 is widely distributed in both invertebrates and vertebrates, and plays a crucial role in tempreture sensing, the role of TRPA1 thermosensation and molecular temperature sensitivity are species-specific. In this review, we summarize the temperature-sensing role of TRPA1 orthologues in terms of molecular, cellular, and behavioural levels. |
format | Online Article Text |
id | pubmed-10120293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-101202932023-05-15 The role of TRPA1 channels in thermosensation Zhang, Hao Wang, Chengsan Zhang, Keyi Kamau, Peter Muiruri Luo, Anna Tian, Lifeng Lai, Ren Cell Insight Review Transient receptor potential ankyrin 1 (TRPA1) is a polymodal nonselective cation channel sensitive to different physical and chemical stimuli. TRPA1 is associated with many important physiological functions in different species and thus is involved in different degrees of evolution. TRPA1 acts as a polymodal receptor for the perceiving of irritating chemicals, cold, heat, and mechanical sensations in various animal species. Numerous studies have supported many functions of TRPA1, but its temperature-sensing function remains controversial. Although TRPA1 is widely distributed in both invertebrates and vertebrates, and plays a crucial role in tempreture sensing, the role of TRPA1 thermosensation and molecular temperature sensitivity are species-specific. In this review, we summarize the temperature-sensing role of TRPA1 orthologues in terms of molecular, cellular, and behavioural levels. Elsevier 2022-10-11 /pmc/articles/PMC10120293/ /pubmed/37193355 http://dx.doi.org/10.1016/j.cellin.2022.100059 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Zhang, Hao Wang, Chengsan Zhang, Keyi Kamau, Peter Muiruri Luo, Anna Tian, Lifeng Lai, Ren The role of TRPA1 channels in thermosensation |
title | The role of TRPA1 channels in thermosensation |
title_full | The role of TRPA1 channels in thermosensation |
title_fullStr | The role of TRPA1 channels in thermosensation |
title_full_unstemmed | The role of TRPA1 channels in thermosensation |
title_short | The role of TRPA1 channels in thermosensation |
title_sort | role of trpa1 channels in thermosensation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120293/ https://www.ncbi.nlm.nih.gov/pubmed/37193355 http://dx.doi.org/10.1016/j.cellin.2022.100059 |
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