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Intertwined regulation between RNA m(6)A modification and cancer metabolism
RNA N6-methyladenosine (m(6)A) has been identified as the most common, abundant and conserved internal modification in RNA transcripts, especially within eukaryotic messenger RNAs (mRNAs). Accumulating evidence demonstrates that RNA m(6)A modification exploits a wide range of regulatory mechanisms t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120304/ https://www.ncbi.nlm.nih.gov/pubmed/37192910 http://dx.doi.org/10.1016/j.cellin.2022.100075 |
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author | Liu, Jiaxu Huang, Hao Zhang, Minghao Qing, Guoliang Liu, Hudan |
author_facet | Liu, Jiaxu Huang, Hao Zhang, Minghao Qing, Guoliang Liu, Hudan |
author_sort | Liu, Jiaxu |
collection | PubMed |
description | RNA N6-methyladenosine (m(6)A) has been identified as the most common, abundant and conserved internal modification in RNA transcripts, especially within eukaryotic messenger RNAs (mRNAs). Accumulating evidence demonstrates that RNA m(6)A modification exploits a wide range of regulatory mechanisms to control gene expression in pathophysiological processes including cancer. Metabolic reprogramming has been widely recognized as a hallmark of cancer. Cancer cells obtain metabolic adaptation through a variety of endogenous and exogenous signaling pathways to promote cell growth and survival in the microenvironment with limited nutrient supply. Recent emerging evidence reveals reciprocal regulation between the m(6)A modification and disordered metabolic events in cancer cells, adding more complexity in the cellular network of metabolic rewiring. In this review, we summarize the most recent advances of how RNA methylation affects tumor metabolism and the feedback regulation of m(6)A modification by metabolic intermediates. We aim to highlight the important connection between RNA m(6)A modification and cancer metabolism, and expect that studise of RNA m(6)A and metabolic reprogramming will lead to greater understanding of cancer pathology. |
format | Online Article Text |
id | pubmed-10120304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-101203042023-05-15 Intertwined regulation between RNA m(6)A modification and cancer metabolism Liu, Jiaxu Huang, Hao Zhang, Minghao Qing, Guoliang Liu, Hudan Cell Insight Review RNA N6-methyladenosine (m(6)A) has been identified as the most common, abundant and conserved internal modification in RNA transcripts, especially within eukaryotic messenger RNAs (mRNAs). Accumulating evidence demonstrates that RNA m(6)A modification exploits a wide range of regulatory mechanisms to control gene expression in pathophysiological processes including cancer. Metabolic reprogramming has been widely recognized as a hallmark of cancer. Cancer cells obtain metabolic adaptation through a variety of endogenous and exogenous signaling pathways to promote cell growth and survival in the microenvironment with limited nutrient supply. Recent emerging evidence reveals reciprocal regulation between the m(6)A modification and disordered metabolic events in cancer cells, adding more complexity in the cellular network of metabolic rewiring. In this review, we summarize the most recent advances of how RNA methylation affects tumor metabolism and the feedback regulation of m(6)A modification by metabolic intermediates. We aim to highlight the important connection between RNA m(6)A modification and cancer metabolism, and expect that studise of RNA m(6)A and metabolic reprogramming will lead to greater understanding of cancer pathology. Elsevier 2022-12-05 /pmc/articles/PMC10120304/ /pubmed/37192910 http://dx.doi.org/10.1016/j.cellin.2022.100075 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liu, Jiaxu Huang, Hao Zhang, Minghao Qing, Guoliang Liu, Hudan Intertwined regulation between RNA m(6)A modification and cancer metabolism |
title | Intertwined regulation between RNA m(6)A modification and cancer metabolism |
title_full | Intertwined regulation between RNA m(6)A modification and cancer metabolism |
title_fullStr | Intertwined regulation between RNA m(6)A modification and cancer metabolism |
title_full_unstemmed | Intertwined regulation between RNA m(6)A modification and cancer metabolism |
title_short | Intertwined regulation between RNA m(6)A modification and cancer metabolism |
title_sort | intertwined regulation between rna m(6)a modification and cancer metabolism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120304/ https://www.ncbi.nlm.nih.gov/pubmed/37192910 http://dx.doi.org/10.1016/j.cellin.2022.100075 |
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