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Herpes simplex virus protein UL56 inhibits cGAS-Mediated DNA sensing to evade antiviral immunity

After herpes simplex virus type 1 (HSV-1) infection, the cytosolic sensor cyclic GMP-AMP synthase (cGAS) recognizes DNA and catalyzes synthesis of the second messenger 2′3′-cGAMP. cGAMP binds to the ER-localized adaptor protein MITA (also known as STING) to activate downstream antiviral responses. C...

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Detalles Bibliográficos
Autores principales:	Zheng, Zhou-Qin, Fu, Yu-Zhi, Wang, Su-Yun, Xu, Zhi-Sheng, Zou, Hong-Mei, Wang, Yan-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120305/ https://www.ncbi.nlm.nih.gov/pubmed/37193132 http://dx.doi.org/10.1016/j.cellin.2022.100014

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