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Regulation and function of the cGAS-MITA/STING axis in health and disease
The innate immune systems detect pathogens via pattern-recognition receptors including nucleic acid sensors and non-nucleic acid sensors. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS, also known as MB21D1) is a cytosolic DNA sensor that recognizes double-stranded DNA...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120319/ https://www.ncbi.nlm.nih.gov/pubmed/37192983 http://dx.doi.org/10.1016/j.cellin.2021.100001 |
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author | Zhang, Zhi-Dong Zhong, Bo |
author_facet | Zhang, Zhi-Dong Zhong, Bo |
author_sort | Zhang, Zhi-Dong |
collection | PubMed |
description | The innate immune systems detect pathogens via pattern-recognition receptors including nucleic acid sensors and non-nucleic acid sensors. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS, also known as MB21D1) is a cytosolic DNA sensor that recognizes double-stranded DNA (dsDNA) and catalyzes the synthesis of 2′,3′-cGAMP. Subsequently, 2′,3′-cGAMP binds to the adaptor protein mediator of IRF3 activation (MITA, also known as STING, MPYS, ERIS, and TMEM173) to activate downstream signaling cascades. The cGAS-MITA/STING signaling critically mediates immune responses against DNA viruses, retroviruses, bacteria, and protozoan parasites. In addition, recent discoveries have extended our understanding of the roles of the cGAS-MITA/STING pathway in autoimmune diseases and cancers. Here, we summarize the identification and activation of cGAS and MITA/STING, present the updated functions and regulatory mechanisms of cGAS-MITA/STING signaling and provide a comprehensive understanding of the cGAS-MITA/STING axis in autoimmune diseases and cancers. |
format | Online Article Text |
id | pubmed-10120319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-101203192023-05-15 Regulation and function of the cGAS-MITA/STING axis in health and disease Zhang, Zhi-Dong Zhong, Bo Cell Insight Review The innate immune systems detect pathogens via pattern-recognition receptors including nucleic acid sensors and non-nucleic acid sensors. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS, also known as MB21D1) is a cytosolic DNA sensor that recognizes double-stranded DNA (dsDNA) and catalyzes the synthesis of 2′,3′-cGAMP. Subsequently, 2′,3′-cGAMP binds to the adaptor protein mediator of IRF3 activation (MITA, also known as STING, MPYS, ERIS, and TMEM173) to activate downstream signaling cascades. The cGAS-MITA/STING signaling critically mediates immune responses against DNA viruses, retroviruses, bacteria, and protozoan parasites. In addition, recent discoveries have extended our understanding of the roles of the cGAS-MITA/STING pathway in autoimmune diseases and cancers. Here, we summarize the identification and activation of cGAS and MITA/STING, present the updated functions and regulatory mechanisms of cGAS-MITA/STING signaling and provide a comprehensive understanding of the cGAS-MITA/STING axis in autoimmune diseases and cancers. Elsevier 2022-01-05 /pmc/articles/PMC10120319/ /pubmed/37192983 http://dx.doi.org/10.1016/j.cellin.2021.100001 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Zhang, Zhi-Dong Zhong, Bo Regulation and function of the cGAS-MITA/STING axis in health and disease |
title | Regulation and function of the cGAS-MITA/STING axis in health and disease |
title_full | Regulation and function of the cGAS-MITA/STING axis in health and disease |
title_fullStr | Regulation and function of the cGAS-MITA/STING axis in health and disease |
title_full_unstemmed | Regulation and function of the cGAS-MITA/STING axis in health and disease |
title_short | Regulation and function of the cGAS-MITA/STING axis in health and disease |
title_sort | regulation and function of the cgas-mita/sting axis in health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120319/ https://www.ncbi.nlm.nih.gov/pubmed/37192983 http://dx.doi.org/10.1016/j.cellin.2021.100001 |
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