Cargando…

Regulation and function of the cGAS-MITA/STING axis in health and disease

The innate immune systems detect pathogens via pattern-recognition receptors including nucleic acid sensors and non-nucleic acid sensors. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS, also known as MB21D1) is a cytosolic DNA sensor that recognizes double-stranded DNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Zhi-Dong, Zhong, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120319/
https://www.ncbi.nlm.nih.gov/pubmed/37192983
http://dx.doi.org/10.1016/j.cellin.2021.100001
_version_ 1785029166983282688
author Zhang, Zhi-Dong
Zhong, Bo
author_facet Zhang, Zhi-Dong
Zhong, Bo
author_sort Zhang, Zhi-Dong
collection PubMed
description The innate immune systems detect pathogens via pattern-recognition receptors including nucleic acid sensors and non-nucleic acid sensors. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS, also known as MB21D1) is a cytosolic DNA sensor that recognizes double-stranded DNA (dsDNA) and catalyzes the synthesis of 2′,3′-cGAMP. Subsequently, 2′,3′-cGAMP binds to the adaptor protein mediator of IRF3 activation (MITA, also known as STING, MPYS, ERIS, and TMEM173) to activate downstream signaling cascades. The cGAS-MITA/STING signaling critically mediates immune responses against DNA viruses, retroviruses, bacteria, and protozoan parasites. In addition, recent discoveries have extended our understanding of the roles of the cGAS-MITA/STING pathway in autoimmune diseases and cancers. Here, we summarize the identification and activation of cGAS and MITA/STING, present the updated functions and regulatory mechanisms of cGAS-MITA/STING signaling and provide a comprehensive understanding of the cGAS-MITA/STING axis in autoimmune diseases and cancers.
format Online
Article
Text
id pubmed-10120319
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-101203192023-05-15 Regulation and function of the cGAS-MITA/STING axis in health and disease Zhang, Zhi-Dong Zhong, Bo Cell Insight Review The innate immune systems detect pathogens via pattern-recognition receptors including nucleic acid sensors and non-nucleic acid sensors. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS, also known as MB21D1) is a cytosolic DNA sensor that recognizes double-stranded DNA (dsDNA) and catalyzes the synthesis of 2′,3′-cGAMP. Subsequently, 2′,3′-cGAMP binds to the adaptor protein mediator of IRF3 activation (MITA, also known as STING, MPYS, ERIS, and TMEM173) to activate downstream signaling cascades. The cGAS-MITA/STING signaling critically mediates immune responses against DNA viruses, retroviruses, bacteria, and protozoan parasites. In addition, recent discoveries have extended our understanding of the roles of the cGAS-MITA/STING pathway in autoimmune diseases and cancers. Here, we summarize the identification and activation of cGAS and MITA/STING, present the updated functions and regulatory mechanisms of cGAS-MITA/STING signaling and provide a comprehensive understanding of the cGAS-MITA/STING axis in autoimmune diseases and cancers. Elsevier 2022-01-05 /pmc/articles/PMC10120319/ /pubmed/37192983 http://dx.doi.org/10.1016/j.cellin.2021.100001 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Zhang, Zhi-Dong
Zhong, Bo
Regulation and function of the cGAS-MITA/STING axis in health and disease
title Regulation and function of the cGAS-MITA/STING axis in health and disease
title_full Regulation and function of the cGAS-MITA/STING axis in health and disease
title_fullStr Regulation and function of the cGAS-MITA/STING axis in health and disease
title_full_unstemmed Regulation and function of the cGAS-MITA/STING axis in health and disease
title_short Regulation and function of the cGAS-MITA/STING axis in health and disease
title_sort regulation and function of the cgas-mita/sting axis in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120319/
https://www.ncbi.nlm.nih.gov/pubmed/37192983
http://dx.doi.org/10.1016/j.cellin.2021.100001
work_keys_str_mv AT zhangzhidong regulationandfunctionofthecgasmitastingaxisinhealthanddisease
AT zhongbo regulationandfunctionofthecgasmitastingaxisinhealthanddisease