Cargando…

Endothelial RGS12 governs angiogenesis in inflammatory arthritis by controlling cilia formation and elongation via MYCBP2 signaling

Angiogenesis is the formation of new capillaries that plays an essential role in the pathogenesis of inflammatory arthritis. However, the cellular and molecular mechanisms remain unclear. Here, we provide the first evidence that regulator of G-protein signaling 12 (RGS12) promotes angiogenesis in in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Gongsheng, Yang, Shu-ting, Yang, Shuying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120324/ https://www.ncbi.nlm.nih.gov/pubmed/37193553 http://dx.doi.org/10.1016/j.cellin.2022.100055

Ejemplares similares

Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling
por: Yuan, Gongsheng, et al.
Publicado: (2022)

RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling
por: Yuan, Gongsheng, et al.
Publicado: (2023)

Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination
por: Yuan, Gongsheng, et al.
Publicado: (2021)

RGS12 Is a Novel Critical NF-κB Activator in Inflammatory Arthritis
por: Yuan, Gongsheng, et al.
Publicado: (2020)

RGS12 is required for the maintenance of mitochondrial function during skeletal development
por: Yuan, Gongsheng, et al.
Publicado: (2020)

RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment
por: Yuan, Gongsheng, et al.
Publicado: (2021)

RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells
por: Akturk, Anil, et al.
Publicado: (2022)

RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling
por: Li, Yang, et al.
Publicado: (2021)

Macrophage regulator of G-protein signaling 12 contributes to inflammatory pain hypersensitivity
por: Yuan, Gongsheng, et al.
Publicado: (2021)

EYA4 inhibits hepatocellular carcinoma by repressing MYCBP by dephosphorylating β‐catenin at Ser552
por: Zhu, Xiao‐Xu, et al.
Publicado: (2019)

MYCBP2 expression correlated with inflammatory cell infiltration and prognosis immunotherapy in thyroid cancer patients
por: Wang, Guilin, et al.
Publicado: (2022)

Dysfunction of ubiquitin protein ligase MYCBP2 leads to cell resilience in human breast cancers
por: Neff, Ryan A, et al.
Publicado: (2023)

Lack of Dopaminergic Inputs Elongates the Primary Cilia of Striatal Neurons
por: Miyoshi, Ko, et al.
Publicado: (2014)

HDAC3 and HDAC8 are required for cilia assembly and elongation
por: Park, Seon-ah, et al.
Publicado: (2019)

Identification of Cilia in Different Mouse Tissues
por: Li, Xinhua, et al.
Publicado: (2021)

Effect of Regulator of G Protein Signaling Proteins on Bone
por: Yuan, Gongsheng, et al.
Publicado: (2022)

Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling
por: Lin, Chuwen, et al.
Publicado: (2014)

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response
por: Wann, A. K. T., et al.
Publicado: (2012)

Identification of Elongated Primary Cilia with Impaired Mechanotransduction in Idiopathic Scoliosis Patients
por: Oliazadeh, Niaz, et al.
Publicado: (2017)

MiR-26b-5p inhibits cell proliferation and EMT by targeting MYCBP in triple-negative breast cancer
por: Ma, Sugang, et al.
Publicado: (2021)

Epigenetically regulated miR-1247 functions as a novel tumour suppressor via MYCBP2 in methylator colon cancers
por: Liang, Jennifer, et al.
Publicado: (2018)

Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
por: Chang, Chao, et al.
Publicado: (2023)

Type II collagen-positive progenitors are important stem cells in controlling skeletal development and vascular formation
por: Li, Xinhua, et al.
Publicado: (2022)

Unilateral nephrectomy elongates primary cilia in the remaining kidney via reactive oxygen species
por: Han, Sang Jun, et al.
Publicado: (2016)

A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation
por: Jiang, Shiyou, et al.
Publicado: (2015)

Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk
por: Guo, Cong-Cong, et al.
Publicado: (2016)

Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia
por: Ge, Zheng, et al.
Publicado: (2015)

lncRNA LUNAR1 accelerates colorectal cancer progression by targeting the miR-495-3p/MYCBP axis
por: Qian, Jiajie, et al.
Publicado: (2020)

Eight RGS and RGS-like Proteins Orchestrate Growth, Differentiation, and Pathogenicity of Magnaporthe oryzae
por: Zhang, Haifeng, et al.
Publicado: (2011)

Characteristics of a Regulator of G-Protein Signaling (RGS) rgsC in Aspergillus fumigatus
por: Kim, Young, et al.
Publicado: (2017)

Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4
por: Borges, Jordana I., et al.
Publicado: (2023)

Screening for genes involved in cilia formation
por: Hall, EA, et al.
Publicado: (2012)

Functions of Endothelial Cilia in the Regulation of Vascular Barriers
por: Ma, Nan, et al.
Publicado: (2020)

Translational control by RGS2
por: Nguyen, Chau H., et al.
Publicado: (2009)

Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon
por: Rowson, Daniel, et al.
Publicado: (2016)

Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis. Iron deficiency and angiogenesis
por: Eckard, Jonathan, et al.
Publicado: (2010)

Correction: Eight RGS and RGS-like Proteins Orchestrate Growth, Differentiation, and Pathogenicity of Magnaporthe oryzae
por: Zhang, Haifeng, et al.
Publicado: (2019)

THE STRUCTURE AND FORMATION OF CILIA AND FILAMENTS IN RUMEN PROTOZOA
por: Roth, L. E., et al.
Publicado: (1964)

CPAP is required for cilia formation in neuronal cells
por: Wu, Kuo-Sheng, et al.
Publicado: (2012)

Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis
por: Vempati, Prakash, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9bq6nrjpfpihv5hi6van4tq9d6