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A governance of ion selectivity based on the occupancy of the “beacon” in one- and four-domain calcium and sodium channels
One of nature’s exceptions was discovered when a Cav3 T-type channel was observed to switch phenotype from a calcium channel into a sodium channel by neutralizing an aspartate residue in the high field strength (HFS) +1 position within the ion selectivity filter. The HFS+1 site is dubbed a “beacon”...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120453/ https://www.ncbi.nlm.nih.gov/pubmed/37075164 http://dx.doi.org/10.1080/19336950.2023.2191773 |