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Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights

Multiple inhibitions of CA, COX-2 and 5-LOX enzymes has been recognised as a useful strategy for the development of anti-inflammatory drugs that can avoid the disadvantages of using NSAIDs alone. Here, we report new pyridazine-based sulphonamides (5a-c and 7a-f) as potential multi-target anti-inflam...

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Detalles Bibliográficos
Autores principales:	Badawi, Waleed A., Rashed, Mahmoud, Nocentini, Alessio, Bonardi, Alessandro, Abd-Alhaseeb, Mohammad M., Al-Rashood, Sara T., Veerakanellore, Giri Babu, Majrashi, Taghreed A., Elkaeed, Eslam B., Elgendy, Bahaa, Gratteri, Paola, Supuran, Claudiu T., Eldehna, Wagdy M., Elagawany, Mohamed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120535/ https://www.ncbi.nlm.nih.gov/pubmed/37078173 http://dx.doi.org/10.1080/14756366.2023.2201407

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