Novel Glu-based pyrazolo[3,4-d]pyrimidine analogues: design, synthesis and biological evaluation as DHFR and TS dual inhibitors

A novel series of multifunctional pyrazolo[3,4-d]pyrimidine-based glutamate analogs (6a–l and 7a,b) have been designed and synthesized as antifolate anticancer agents. Among the tested compounds, 6i exhibited the most potent anti-proliferative activity towards NSCLC, CNS, Ovarian, Prostate, Colon, M...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahnashi, Mater, Alshahrani, Mohammed Merae, Al Ali, Amer, Asiri, Abdulaziz, Abou-Salim, Mahrous A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120551/
https://www.ncbi.nlm.nih.gov/pubmed/37080777
http://dx.doi.org/10.1080/14756366.2023.2203879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120551/
https://www.ncbi.nlm.nih.gov/pubmed/37080777
http://dx.doi.org/10.1080/14756366.2023.2203879

Ejemplares similares