Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

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PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from activated GPCRs. PI3Kγ can form two distinct complexes, with the p110γ catalytic subunit binding to either a p101 or p...

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Detalles Bibliográficos
Autores principales: Harris, Noah J, Jenkins, Meredith L, Nam, Sung-Eun, Rathinaswamy, Manoj K, Parson, Matthew AH, Ranga-Prasad, Harish, Dalwadi, Udit, Moeller, Brandon E, Sheekey, Eleanor, Hansen, Scott D, Yip, Calvin K, Burke, John E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120615/
https://www.ncbi.nlm.nih.gov/pubmed/37090531
http://dx.doi.org/10.1101/2023.04.12.536585
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