A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube Defects

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Neural tube defects (NTDs) including anencephaly and spina bifida are common major malformations of fetal development resulting from incomplete closure of the neural tube. These conditions lead to either universal death (anencephaly) or life-long severe complications (spina bifida). Despite hundreds...

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Detalles Bibliográficos
Autores principales: Takla, Taylor N., Luo, Jinghui, Sudyk, Roksolana, Huang, Joy, Walker, J. Clayton, Vora, Neeta L., Sexton, Jonathan Z., Parent, Jack M., Tidball, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120643/
https://www.ncbi.nlm.nih.gov/pubmed/37090564
http://dx.doi.org/10.1101/2023.04.11.536245

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