Mutation signature filtering enables high-fidelity RNA structure probing at all four nucleobases with DMS

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Chemical probing experiments have transformed RNA structure analysis, enabling high-throughput measurement of base-pairing in living cells. Dimethyl sulfate (DMS) is one of the most widely used structure probing reagents and has played a prominent role in enabling next-generation single-molecule pro...

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Detalles Bibliográficos
Autores principales: Mitchell, David, Cotter, Jennifer, Saleem, Irfana, Mustoe, Anthony M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120657/
https://www.ncbi.nlm.nih.gov/pubmed/37090560
http://dx.doi.org/10.1101/2023.04.10.536308

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