Genetic regulation of cell-type specific chromatin accessibility shapes the etiology of brain diseases

Nucleotide variants in cell type-specific gene regulatory elements in the human brain are major risk factors of human disease. We measured chromatin accessibility in sorted neurons and glia from 1,932 samples of human postmortem brain and identified 34,539 open chromatin regions with chromatin acces...

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Detalles Bibliográficos
Autores principales: Zeng, Biao, Bendl, Jaroslav, Deng, Chengyu, Lee, Donghoon, Misir, Ruth, Reach, Sarah M., Kleopoulos, Steven P., Auluck, Pavan, Marenco, Stefano, Lewis, David A., Haroutunian, Vahram, Ahituv, Nadav, Fullard, John F., Hoffman, Gabriel E., Roussos, Panos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120699/
https://www.ncbi.nlm.nih.gov/pubmed/37090548
http://dx.doi.org/10.1101/2023.03.02.530826

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