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Adolescent morphine exposure impairs cognitive flexibility in female but not male mice

Use of prescription opioids continues to rise, especially in adolescent individuals. As adolescence is a critical development window for higher order cognitive functions, thus opioid exposure during this period may have significant long-lasting effects on cognitive function and predisposition indivi...

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Autores principales: Wakhlu, Aditii, Engelhardt, Annabel, Anderson, Eden M., Grafelman, Elaine, Ouimet, Abbigail, Hearing, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120710/
https://www.ncbi.nlm.nih.gov/pubmed/37090510
http://dx.doi.org/10.1101/2023.04.09.536177
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author Wakhlu, Aditii
Engelhardt, Annabel
Anderson, Eden M.
Grafelman, Elaine
Ouimet, Abbigail
Hearing, Matthew C.
author_facet Wakhlu, Aditii
Engelhardt, Annabel
Anderson, Eden M.
Grafelman, Elaine
Ouimet, Abbigail
Hearing, Matthew C.
author_sort Wakhlu, Aditii
collection PubMed
description Use of prescription opioids continues to rise, especially in adolescent individuals. As adolescence is a critical development window for higher order cognitive functions, thus opioid exposure during this period may have significant long-lasting effects on cognitive function and predisposition individuals to be at greater risk of developing opioid use later in life. Here, we examine previously explored effects of opioid exposure during adolescence on affect-related behavior, motivation, and cognitive flexibility. We find that a two-week exposure to non-contingent morphine during adolescence (i.e., post-weaning) does not alter performance in an elevated plus maze, forced swim test, or motivation for appetitive reward in male or female mice when tested during adolescence or adulthood. Examination of how adolescent morphine impacts cognition revealed impairments in visual-based discriminative learning and cognitive flexibility in female but not male mice, as assessed using an operant-based attentional set-shifting task. Unexpectedly, deficits in discriminative learning are observed when testing occurred during adolescence but not adulthood, whereas impaired performance in the extradimensional shift remained impaired into adulthood. The data indicate that opioid exposure during adolescence has a greater impact on cognitive function in female mice and that these deficits may be more widespread during acute withdrawal periods, while deficits in flexibility more enduring.
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spelling pubmed-101207102023-04-22 Adolescent morphine exposure impairs cognitive flexibility in female but not male mice Wakhlu, Aditii Engelhardt, Annabel Anderson, Eden M. Grafelman, Elaine Ouimet, Abbigail Hearing, Matthew C. bioRxiv Article Use of prescription opioids continues to rise, especially in adolescent individuals. As adolescence is a critical development window for higher order cognitive functions, thus opioid exposure during this period may have significant long-lasting effects on cognitive function and predisposition individuals to be at greater risk of developing opioid use later in life. Here, we examine previously explored effects of opioid exposure during adolescence on affect-related behavior, motivation, and cognitive flexibility. We find that a two-week exposure to non-contingent morphine during adolescence (i.e., post-weaning) does not alter performance in an elevated plus maze, forced swim test, or motivation for appetitive reward in male or female mice when tested during adolescence or adulthood. Examination of how adolescent morphine impacts cognition revealed impairments in visual-based discriminative learning and cognitive flexibility in female but not male mice, as assessed using an operant-based attentional set-shifting task. Unexpectedly, deficits in discriminative learning are observed when testing occurred during adolescence but not adulthood, whereas impaired performance in the extradimensional shift remained impaired into adulthood. The data indicate that opioid exposure during adolescence has a greater impact on cognitive function in female mice and that these deficits may be more widespread during acute withdrawal periods, while deficits in flexibility more enduring. Cold Spring Harbor Laboratory 2023-04-10 /pmc/articles/PMC10120710/ /pubmed/37090510 http://dx.doi.org/10.1101/2023.04.09.536177 Text en https://creativecommons.org/licenses/by-nd/4.0/This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, and only so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Wakhlu, Aditii
Engelhardt, Annabel
Anderson, Eden M.
Grafelman, Elaine
Ouimet, Abbigail
Hearing, Matthew C.
Adolescent morphine exposure impairs cognitive flexibility in female but not male mice
title Adolescent morphine exposure impairs cognitive flexibility in female but not male mice
title_full Adolescent morphine exposure impairs cognitive flexibility in female but not male mice
title_fullStr Adolescent morphine exposure impairs cognitive flexibility in female but not male mice
title_full_unstemmed Adolescent morphine exposure impairs cognitive flexibility in female but not male mice
title_short Adolescent morphine exposure impairs cognitive flexibility in female but not male mice
title_sort adolescent morphine exposure impairs cognitive flexibility in female but not male mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120710/
https://www.ncbi.nlm.nih.gov/pubmed/37090510
http://dx.doi.org/10.1101/2023.04.09.536177
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