MAPT expression is mediated by long-range interactions with cis-regulatory elements

BACKGROUND: Tauopathies are a group of neurodegenerative diseases driven by abnormal aggregates of tau, a microtubule associated protein encoded by the MAPT gene. MAPT expression is absent in neural progenitor cells (NPCs) and increases during differentiation. This temporally dynamic expression patt...

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Detalles Bibliográficos
Autores principales: Rogers, Brianne B., Anderson, Ashlyn G., Lauzon, Shelby N., Davis, M. Natalie, Hauser, Rebecca M., Roberts, Sydney C., Rodriguez-Nunez, Ivan, Trausch-Lowther, Katie, Barinaga, Erin A., Taylor, Jared W., Mackiewicz, Mark, Roberts, Brian S., Cooper, Sara J., Rizzardi, Lindsay F., Myers, Richard M., Cochran, J. Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120716/
https://www.ncbi.nlm.nih.gov/pubmed/37090552
http://dx.doi.org/10.1101/2023.03.07.531520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120716/
https://www.ncbi.nlm.nih.gov/pubmed/37090552
http://dx.doi.org/10.1101/2023.03.07.531520

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