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Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction

BACKGROUND: Genetic variants can contribute differently to trait heritability by their functional categories, and recent studies have shown that incorporating functional annotation can improve the predictive performance of polygenic risk scores (PRSs). In addition, when only a small proportion of va...

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Detalles Bibliográficos
Autores principales:	Zhuang, Yongwen, Kim, Na Yeon, Fritsche, Lars G., Mukherjee, Bhramar, Lee, Seunggeun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120759/ https://www.ncbi.nlm.nih.gov/pubmed/37090583 http://dx.doi.org/10.21203/rs.3.rs-2759690/v1

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