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Diminazene Ameliorates Neuroinflammation by Suppression of Astrocytic miRNA-224-5p/NLRP3 Axis in Alzheimer’s Disease Model

PURPOSE: ACE2/Ang(1–7)/Mas Receptor, the momentous component of the renin-angiotensin system, has been shown to be involved in Alzheimer’s disease (AD). We had previously found that enhancing brain ACE2 activity ameliorated cognitive impairment and attenuated brain neuroinflammation in SAMP8 mice, a...

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Detalles Bibliográficos
Autores principales:	Sun, XiaoJin, Deng, Yang, Ge, PengXin, Peng, Qiang, Soufiany, Ismatullah, Zhu, Lin, Duan, Rui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120828/ https://www.ncbi.nlm.nih.gov/pubmed/37092127 http://dx.doi.org/10.2147/JIR.S401385

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