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Maternal infections in pregnancy and the risk of sudden unexpected infant death in the offspring in the U.S., 2011–2015
BACKGROUND: Infection is thought to play a part in some infant deaths. Maternal infection in pregnancy has focused on chlamydia with some reports suggesting an association with sudden unexpected infant death (SUID). OBJECTIVES: We hypothesized that maternal infections in pregnancy are associated wit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121007/ https://www.ncbi.nlm.nih.gov/pubmed/37083949 http://dx.doi.org/10.1371/journal.pone.0284614 |
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author | Weatherly, Maggie Trivedi, Anusua Chembrolu, Ratna Gupta, Sanjana Ramirez, Jan-Marino Lavista Ferres, Juan M. Anderson, Tatiana M. Mitchell, Edwin A. |
author_facet | Weatherly, Maggie Trivedi, Anusua Chembrolu, Ratna Gupta, Sanjana Ramirez, Jan-Marino Lavista Ferres, Juan M. Anderson, Tatiana M. Mitchell, Edwin A. |
author_sort | Weatherly, Maggie |
collection | PubMed |
description | BACKGROUND: Infection is thought to play a part in some infant deaths. Maternal infection in pregnancy has focused on chlamydia with some reports suggesting an association with sudden unexpected infant death (SUID). OBJECTIVES: We hypothesized that maternal infections in pregnancy are associated with subsequent SUID in their offspring. SETTING: All births in the United States, 2011–2015 DATA SOURCE: Centers for Disease Control and Prevention (CDC) Birth Cohort Linked Birth-Infant Death Data Files. STUDY DESIGN: Cohort study, although the data were analysed as a case control study. Cases were infants that died from SUID. Controls were randomly sampled infants that survived their first year of life; approximately 10 controls per SUID case. EXPOSURES: Chlamydia, gonorrhea and hepatitis C. RESULTS: There were 19,849,690 live births in the U.S. for the period 2011–2015. There were 37,143 infant deaths of which 17,398 were classified as SUID cases (a rate of 0.86/1000 live births). The proportion of the control mothers with chlamydia was 1.7%, gonorrhea 0.2% and hepatitis C was 0.3%. Chlamydia was present in 3.8% of mothers whose infants subsequently died of SUID compared with 1.7% of controls (unadjusted OR = 2.35, 95% CI = 2.15, 2.56; adjusted OR = 1.08, 95% CI = 0.98, 1.19). Gonorrhea was present in 0.7% of mothers of SUID cases compared with 0.2% of mothers of controls (OR = 3.09, (2.50, 3.79); aOR = 1.20(0.95, 1.49)) and hepatitis C was present in 1.3% of mothers of SUID cases compared with 0.3% of mothers of controls (OR = 4.69 (3.97, 5.52): aOR = 1.80 (1.50, 2.15)). CONCLUSIONS: The marked attenuation of SUID risk after adjustment for a wide variety of socioeconomic and demographic factors suggests the small increase in the risk of SUID of the offspring of mothers with infection with hepatitis C in pregnancy is due to residual confounding. |
format | Online Article Text |
id | pubmed-10121007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-101210072023-04-22 Maternal infections in pregnancy and the risk of sudden unexpected infant death in the offspring in the U.S., 2011–2015 Weatherly, Maggie Trivedi, Anusua Chembrolu, Ratna Gupta, Sanjana Ramirez, Jan-Marino Lavista Ferres, Juan M. Anderson, Tatiana M. Mitchell, Edwin A. PLoS One Research Article BACKGROUND: Infection is thought to play a part in some infant deaths. Maternal infection in pregnancy has focused on chlamydia with some reports suggesting an association with sudden unexpected infant death (SUID). OBJECTIVES: We hypothesized that maternal infections in pregnancy are associated with subsequent SUID in their offspring. SETTING: All births in the United States, 2011–2015 DATA SOURCE: Centers for Disease Control and Prevention (CDC) Birth Cohort Linked Birth-Infant Death Data Files. STUDY DESIGN: Cohort study, although the data were analysed as a case control study. Cases were infants that died from SUID. Controls were randomly sampled infants that survived their first year of life; approximately 10 controls per SUID case. EXPOSURES: Chlamydia, gonorrhea and hepatitis C. RESULTS: There were 19,849,690 live births in the U.S. for the period 2011–2015. There were 37,143 infant deaths of which 17,398 were classified as SUID cases (a rate of 0.86/1000 live births). The proportion of the control mothers with chlamydia was 1.7%, gonorrhea 0.2% and hepatitis C was 0.3%. Chlamydia was present in 3.8% of mothers whose infants subsequently died of SUID compared with 1.7% of controls (unadjusted OR = 2.35, 95% CI = 2.15, 2.56; adjusted OR = 1.08, 95% CI = 0.98, 1.19). Gonorrhea was present in 0.7% of mothers of SUID cases compared with 0.2% of mothers of controls (OR = 3.09, (2.50, 3.79); aOR = 1.20(0.95, 1.49)) and hepatitis C was present in 1.3% of mothers of SUID cases compared with 0.3% of mothers of controls (OR = 4.69 (3.97, 5.52): aOR = 1.80 (1.50, 2.15)). CONCLUSIONS: The marked attenuation of SUID risk after adjustment for a wide variety of socioeconomic and demographic factors suggests the small increase in the risk of SUID of the offspring of mothers with infection with hepatitis C in pregnancy is due to residual confounding. Public Library of Science 2023-04-21 /pmc/articles/PMC10121007/ /pubmed/37083949 http://dx.doi.org/10.1371/journal.pone.0284614 Text en © 2023 Weatherly et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Weatherly, Maggie Trivedi, Anusua Chembrolu, Ratna Gupta, Sanjana Ramirez, Jan-Marino Lavista Ferres, Juan M. Anderson, Tatiana M. Mitchell, Edwin A. Maternal infections in pregnancy and the risk of sudden unexpected infant death in the offspring in the U.S., 2011–2015 |
title | Maternal infections in pregnancy and the risk of sudden unexpected infant death in the offspring in the U.S., 2011–2015 |
title_full | Maternal infections in pregnancy and the risk of sudden unexpected infant death in the offspring in the U.S., 2011–2015 |
title_fullStr | Maternal infections in pregnancy and the risk of sudden unexpected infant death in the offspring in the U.S., 2011–2015 |
title_full_unstemmed | Maternal infections in pregnancy and the risk of sudden unexpected infant death in the offspring in the U.S., 2011–2015 |
title_short | Maternal infections in pregnancy and the risk of sudden unexpected infant death in the offspring in the U.S., 2011–2015 |
title_sort | maternal infections in pregnancy and the risk of sudden unexpected infant death in the offspring in the u.s., 2011–2015 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121007/ https://www.ncbi.nlm.nih.gov/pubmed/37083949 http://dx.doi.org/10.1371/journal.pone.0284614 |
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