Delivering a toxic metal to the active site of urease

Urease is a nickel (Ni) enzyme that is essential for the colonization of Helicobacter pylori in the human stomach. To solve the problem of delivering the toxic Ni ion to the active site without diffusing into the cytoplasm, cells have evolved metal carrier proteins, or metallochaperones, to deliver...

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Detalles Bibliográficos
Autores principales: Nim, Yap Shing, Fong, Ivan Yu Hang, Deme, Justin, Tsang, Ka Lung, Caesar, Joseph, Johnson, Steven, Pang, Longson Tsz Hin, Yuen, Nicholas Man Hon, Ng, Tin Long Chris, Choi, Tung, Wong, Yakie Yat Hei, Lea, Susan M., Wong, Kam-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121161/
https://www.ncbi.nlm.nih.gov/pubmed/37083535
http://dx.doi.org/10.1126/sciadv.adf7790

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