Cargando…

The synovial environment steers cartilage deterioration and regeneration

Osteoarthritis (OA) was recently defined as an epidemic, and the lack of effective treatment is highly correlated to the limited knowledge regarding the underlying pathophysiology. Failure to regenerate upon trauma is thought to be one of the underlying causes for degenerative diseases, including OA...

Descripción completa

Detalles Bibliográficos
Autores principales: Bolander, Johanna, Moviglia Brandolina, Maria Teresita, Poehling, Gary, Jochl, Olivia, Parsons, Emma, Vaughan, William, Moviglia, Gustavo, Atala, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121162/
https://www.ncbi.nlm.nih.gov/pubmed/37083524
http://dx.doi.org/10.1126/sciadv.ade4645
_version_ 1785029324271779840
author Bolander, Johanna
Moviglia Brandolina, Maria Teresita
Poehling, Gary
Jochl, Olivia
Parsons, Emma
Vaughan, William
Moviglia, Gustavo
Atala, Anthony
author_facet Bolander, Johanna
Moviglia Brandolina, Maria Teresita
Poehling, Gary
Jochl, Olivia
Parsons, Emma
Vaughan, William
Moviglia, Gustavo
Atala, Anthony
author_sort Bolander, Johanna
collection PubMed
description Osteoarthritis (OA) was recently defined as an epidemic, and the lack of effective treatment is highly correlated to the limited knowledge regarding the underlying pathophysiology. Failure to regenerate upon trauma is thought to be one of the underlying causes for degenerative diseases, including OA. To investigate why lesions within an OA environment fail to heal, a heterogeneous cell population was isolated from the synovial fluid (SF) of OA patients. The cells’ ability to undergo processes required for functional tissue regeneration was evaluated in the presence or absence of autologous SF. The obtained mechanistic findings were then used for the development of an immunomodulatory cell treatment, aimed to restore the pro-regenerative environment. Intra-articular injection in a clinical compassionate use study showed that the treatment restored the articular cartilage and joint homeostasis of OA patients. These findings confirm the role of pro-regenerative immune cells and their targeted influence on progenitor cells for degenerative joint disease therapies.
format Online
Article
Text
id pubmed-10121162
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher American Association for the Advancement of Science
record_format MEDLINE/PubMed
spelling pubmed-101211622023-04-22 The synovial environment steers cartilage deterioration and regeneration Bolander, Johanna Moviglia Brandolina, Maria Teresita Poehling, Gary Jochl, Olivia Parsons, Emma Vaughan, William Moviglia, Gustavo Atala, Anthony Sci Adv Biomedicine and Life Sciences Osteoarthritis (OA) was recently defined as an epidemic, and the lack of effective treatment is highly correlated to the limited knowledge regarding the underlying pathophysiology. Failure to regenerate upon trauma is thought to be one of the underlying causes for degenerative diseases, including OA. To investigate why lesions within an OA environment fail to heal, a heterogeneous cell population was isolated from the synovial fluid (SF) of OA patients. The cells’ ability to undergo processes required for functional tissue regeneration was evaluated in the presence or absence of autologous SF. The obtained mechanistic findings were then used for the development of an immunomodulatory cell treatment, aimed to restore the pro-regenerative environment. Intra-articular injection in a clinical compassionate use study showed that the treatment restored the articular cartilage and joint homeostasis of OA patients. These findings confirm the role of pro-regenerative immune cells and their targeted influence on progenitor cells for degenerative joint disease therapies. American Association for the Advancement of Science 2023-04-21 /pmc/articles/PMC10121162/ /pubmed/37083524 http://dx.doi.org/10.1126/sciadv.ade4645 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Bolander, Johanna
Moviglia Brandolina, Maria Teresita
Poehling, Gary
Jochl, Olivia
Parsons, Emma
Vaughan, William
Moviglia, Gustavo
Atala, Anthony
The synovial environment steers cartilage deterioration and regeneration
title The synovial environment steers cartilage deterioration and regeneration
title_full The synovial environment steers cartilage deterioration and regeneration
title_fullStr The synovial environment steers cartilage deterioration and regeneration
title_full_unstemmed The synovial environment steers cartilage deterioration and regeneration
title_short The synovial environment steers cartilage deterioration and regeneration
title_sort synovial environment steers cartilage deterioration and regeneration
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121162/
https://www.ncbi.nlm.nih.gov/pubmed/37083524
http://dx.doi.org/10.1126/sciadv.ade4645
work_keys_str_mv AT bolanderjohanna thesynovialenvironmentsteerscartilagedeteriorationandregeneration
AT movigliabrandolinamariateresita thesynovialenvironmentsteerscartilagedeteriorationandregeneration
AT poehlinggary thesynovialenvironmentsteerscartilagedeteriorationandregeneration
AT jochlolivia thesynovialenvironmentsteerscartilagedeteriorationandregeneration
AT parsonsemma thesynovialenvironmentsteerscartilagedeteriorationandregeneration
AT vaughanwilliam thesynovialenvironmentsteerscartilagedeteriorationandregeneration
AT movigliagustavo thesynovialenvironmentsteerscartilagedeteriorationandregeneration
AT atalaanthony thesynovialenvironmentsteerscartilagedeteriorationandregeneration
AT bolanderjohanna synovialenvironmentsteerscartilagedeteriorationandregeneration
AT movigliabrandolinamariateresita synovialenvironmentsteerscartilagedeteriorationandregeneration
AT poehlinggary synovialenvironmentsteerscartilagedeteriorationandregeneration
AT jochlolivia synovialenvironmentsteerscartilagedeteriorationandregeneration
AT parsonsemma synovialenvironmentsteerscartilagedeteriorationandregeneration
AT vaughanwilliam synovialenvironmentsteerscartilagedeteriorationandregeneration
AT movigliagustavo synovialenvironmentsteerscartilagedeteriorationandregeneration
AT atalaanthony synovialenvironmentsteerscartilagedeteriorationandregeneration