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The synovial environment steers cartilage deterioration and regeneration
Osteoarthritis (OA) was recently defined as an epidemic, and the lack of effective treatment is highly correlated to the limited knowledge regarding the underlying pathophysiology. Failure to regenerate upon trauma is thought to be one of the underlying causes for degenerative diseases, including OA...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121162/ https://www.ncbi.nlm.nih.gov/pubmed/37083524 http://dx.doi.org/10.1126/sciadv.ade4645 |
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author | Bolander, Johanna Moviglia Brandolina, Maria Teresita Poehling, Gary Jochl, Olivia Parsons, Emma Vaughan, William Moviglia, Gustavo Atala, Anthony |
author_facet | Bolander, Johanna Moviglia Brandolina, Maria Teresita Poehling, Gary Jochl, Olivia Parsons, Emma Vaughan, William Moviglia, Gustavo Atala, Anthony |
author_sort | Bolander, Johanna |
collection | PubMed |
description | Osteoarthritis (OA) was recently defined as an epidemic, and the lack of effective treatment is highly correlated to the limited knowledge regarding the underlying pathophysiology. Failure to regenerate upon trauma is thought to be one of the underlying causes for degenerative diseases, including OA. To investigate why lesions within an OA environment fail to heal, a heterogeneous cell population was isolated from the synovial fluid (SF) of OA patients. The cells’ ability to undergo processes required for functional tissue regeneration was evaluated in the presence or absence of autologous SF. The obtained mechanistic findings were then used for the development of an immunomodulatory cell treatment, aimed to restore the pro-regenerative environment. Intra-articular injection in a clinical compassionate use study showed that the treatment restored the articular cartilage and joint homeostasis of OA patients. These findings confirm the role of pro-regenerative immune cells and their targeted influence on progenitor cells for degenerative joint disease therapies. |
format | Online Article Text |
id | pubmed-10121162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-101211622023-04-22 The synovial environment steers cartilage deterioration and regeneration Bolander, Johanna Moviglia Brandolina, Maria Teresita Poehling, Gary Jochl, Olivia Parsons, Emma Vaughan, William Moviglia, Gustavo Atala, Anthony Sci Adv Biomedicine and Life Sciences Osteoarthritis (OA) was recently defined as an epidemic, and the lack of effective treatment is highly correlated to the limited knowledge regarding the underlying pathophysiology. Failure to regenerate upon trauma is thought to be one of the underlying causes for degenerative diseases, including OA. To investigate why lesions within an OA environment fail to heal, a heterogeneous cell population was isolated from the synovial fluid (SF) of OA patients. The cells’ ability to undergo processes required for functional tissue regeneration was evaluated in the presence or absence of autologous SF. The obtained mechanistic findings were then used for the development of an immunomodulatory cell treatment, aimed to restore the pro-regenerative environment. Intra-articular injection in a clinical compassionate use study showed that the treatment restored the articular cartilage and joint homeostasis of OA patients. These findings confirm the role of pro-regenerative immune cells and their targeted influence on progenitor cells for degenerative joint disease therapies. American Association for the Advancement of Science 2023-04-21 /pmc/articles/PMC10121162/ /pubmed/37083524 http://dx.doi.org/10.1126/sciadv.ade4645 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Bolander, Johanna Moviglia Brandolina, Maria Teresita Poehling, Gary Jochl, Olivia Parsons, Emma Vaughan, William Moviglia, Gustavo Atala, Anthony The synovial environment steers cartilage deterioration and regeneration |
title | The synovial environment steers cartilage deterioration and regeneration |
title_full | The synovial environment steers cartilage deterioration and regeneration |
title_fullStr | The synovial environment steers cartilage deterioration and regeneration |
title_full_unstemmed | The synovial environment steers cartilage deterioration and regeneration |
title_short | The synovial environment steers cartilage deterioration and regeneration |
title_sort | synovial environment steers cartilage deterioration and regeneration |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121162/ https://www.ncbi.nlm.nih.gov/pubmed/37083524 http://dx.doi.org/10.1126/sciadv.ade4645 |
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