Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects

Ciliopathies manifest from sensory abnormalities to syndromic disorders with multi-organ pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell death is a major cause of incurable blindness in retinal ciliopathies. To identify drug candidates to maintain photorecepto...

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Detalles Bibliográficos
Autores principales: Chen, Holly Y, Swaroop, Manju, Papal, Samantha, Mondal, Anupam K, Song, Hyun Beom, Campello, Laura, Tawa, Gregory J, Regent, Florian, Shimada, Hiroko, Nagashima, Kunio, de Val, Natalia, Jacobson, Samuel G, Zheng, Wei, Swaroop, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121224/
https://www.ncbi.nlm.nih.gov/pubmed/36975211
http://dx.doi.org/10.7554/eLife.83205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121224/
https://www.ncbi.nlm.nih.gov/pubmed/36975211
http://dx.doi.org/10.7554/eLife.83205

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