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Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study
Inflammation is proposed to be involved in the pathogenesis of poststroke cognitive impairment. The aim of this study was to investigate associations between concentrations of systemic inflammatory biomarkers after ischemic stroke and poststroke cognitive impairment. METHODS: The Nor-COAST study (No...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121247/ https://www.ncbi.nlm.nih.gov/pubmed/37026459 http://dx.doi.org/10.1161/STROKEAHA.122.041965 |
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author | Sandvig, Heidi Vihovde Aam, Stina Alme, Katinka Nordheim Askim, Torunn Beyer, Mona K. Ellekjær, Hanne Ihle-Hansen, Hege Lydersen, Stian Mollnes, Tom Eirik Munthe-Kaas, Ragnhild Næss, Halvor Saltvedt, Ingvild Seljeseth, Yngve Müller Thingstad, Pernille Wethal, Torgeir Knapskog, Anne-Brita |
author_facet | Sandvig, Heidi Vihovde Aam, Stina Alme, Katinka Nordheim Askim, Torunn Beyer, Mona K. Ellekjær, Hanne Ihle-Hansen, Hege Lydersen, Stian Mollnes, Tom Eirik Munthe-Kaas, Ragnhild Næss, Halvor Saltvedt, Ingvild Seljeseth, Yngve Müller Thingstad, Pernille Wethal, Torgeir Knapskog, Anne-Brita |
author_sort | Sandvig, Heidi Vihovde |
collection | PubMed |
description | Inflammation is proposed to be involved in the pathogenesis of poststroke cognitive impairment. The aim of this study was to investigate associations between concentrations of systemic inflammatory biomarkers after ischemic stroke and poststroke cognitive impairment. METHODS: The Nor-COAST study (Norwegian Cognitive Impairment After Stroke) is a prospective observational multicenter cohort study, including patients hospitalized with acute stroke between 2015 and 2017. Inflammatory biomarkers, including the TCC (terminal C5b-9 complement complex) and 20 cytokines, were analyzed in plasma, collected at baseline, 3-, and 18 months poststroke, using ELISA and a multiplex assay. Global cognitive outcome was assessed with the Montreal Cognitive Assessment (MoCA) scale. We investigated the associations between plasma inflammatory biomarkers at baseline and MoCA score at 3-, 18-, and 36-month follow-ups; the associations between inflammatory biomarkers at 3 months and MoCA score at 18- and 36-month follow-ups; and the association between these biomarkers at 18 months and MoCA score at 36-month follow-up. We used mixed linear regression adjusted for age and sex. RESULTS: We included 455 survivors of ischemic stroke. Higher concentrations of 7 baseline biomarkers were significantly associated with lower MoCA score at 36 months; TCC, IL (interleukin)-6, and MIP (macrophage inflammatory protein)-1α were associated with MoCA at 3, 18, and 36 months (P<0.01). No biomarker at 3 months was significantly associated with MoCA score at either 18 or 36 months, whereas higher concentrations of 3 biomarkers at 18 months were associated with lower MoCA score at 36 months (P<0.01). TCC at baseline and IL-6 and MIP-1α measured both at baseline and 18 months were particularly strongly associated with MoCA (P<0.01). CONCLUSIONS: Higher concentrations of plasma inflammatory biomarkers were associated with lower MoCA scores up to 36 months poststroke. This was most pronounced for inflammatory biomarkers measured in the acute phase following stroke. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02650531. |
format | Online Article Text |
id | pubmed-10121247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-101212472023-04-24 Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study Sandvig, Heidi Vihovde Aam, Stina Alme, Katinka Nordheim Askim, Torunn Beyer, Mona K. Ellekjær, Hanne Ihle-Hansen, Hege Lydersen, Stian Mollnes, Tom Eirik Munthe-Kaas, Ragnhild Næss, Halvor Saltvedt, Ingvild Seljeseth, Yngve Müller Thingstad, Pernille Wethal, Torgeir Knapskog, Anne-Brita Stroke Original Contributions Inflammation is proposed to be involved in the pathogenesis of poststroke cognitive impairment. The aim of this study was to investigate associations between concentrations of systemic inflammatory biomarkers after ischemic stroke and poststroke cognitive impairment. METHODS: The Nor-COAST study (Norwegian Cognitive Impairment After Stroke) is a prospective observational multicenter cohort study, including patients hospitalized with acute stroke between 2015 and 2017. Inflammatory biomarkers, including the TCC (terminal C5b-9 complement complex) and 20 cytokines, were analyzed in plasma, collected at baseline, 3-, and 18 months poststroke, using ELISA and a multiplex assay. Global cognitive outcome was assessed with the Montreal Cognitive Assessment (MoCA) scale. We investigated the associations between plasma inflammatory biomarkers at baseline and MoCA score at 3-, 18-, and 36-month follow-ups; the associations between inflammatory biomarkers at 3 months and MoCA score at 18- and 36-month follow-ups; and the association between these biomarkers at 18 months and MoCA score at 36-month follow-up. We used mixed linear regression adjusted for age and sex. RESULTS: We included 455 survivors of ischemic stroke. Higher concentrations of 7 baseline biomarkers were significantly associated with lower MoCA score at 36 months; TCC, IL (interleukin)-6, and MIP (macrophage inflammatory protein)-1α were associated with MoCA at 3, 18, and 36 months (P<0.01). No biomarker at 3 months was significantly associated with MoCA score at either 18 or 36 months, whereas higher concentrations of 3 biomarkers at 18 months were associated with lower MoCA score at 36 months (P<0.01). TCC at baseline and IL-6 and MIP-1α measured both at baseline and 18 months were particularly strongly associated with MoCA (P<0.01). CONCLUSIONS: Higher concentrations of plasma inflammatory biomarkers were associated with lower MoCA scores up to 36 months poststroke. This was most pronounced for inflammatory biomarkers measured in the acute phase following stroke. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02650531. Lippincott Williams & Wilkins 2023-04-07 2023-05 /pmc/articles/PMC10121247/ /pubmed/37026459 http://dx.doi.org/10.1161/STROKEAHA.122.041965 Text en © 2023 The Authors. https://creativecommons.org/licenses/by-nc-nd/4.0/Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
spellingShingle | Original Contributions Sandvig, Heidi Vihovde Aam, Stina Alme, Katinka Nordheim Askim, Torunn Beyer, Mona K. Ellekjær, Hanne Ihle-Hansen, Hege Lydersen, Stian Mollnes, Tom Eirik Munthe-Kaas, Ragnhild Næss, Halvor Saltvedt, Ingvild Seljeseth, Yngve Müller Thingstad, Pernille Wethal, Torgeir Knapskog, Anne-Brita Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study |
title | Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study |
title_full | Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study |
title_fullStr | Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study |
title_full_unstemmed | Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study |
title_short | Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study |
title_sort | plasma inflammatory biomarkers are associated with poststroke cognitive impairment: the nor-coast study |
topic | Original Contributions |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121247/ https://www.ncbi.nlm.nih.gov/pubmed/37026459 http://dx.doi.org/10.1161/STROKEAHA.122.041965 |
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