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RETINAL TOXICITY FOLLOWING PRESUMED INADVERTENT INTRAOCULAR INJECTION OF MITOMYCIN C DURING TRABECULECTOMY

To describe a case of postoperative retinal toxicity following the use of mitomycin C during a routine trabeculectomy. METHODS: Case report of a single patient who underwent complete ophthalmic examination and multimodal imaging, including color fundus photos, optical coherence tomography, fundus au...

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Autores principales: Desai, Ria, Jampol, Lee M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Retinal Cases & Brief Reports 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121365/
https://www.ncbi.nlm.nih.gov/pubmed/34293779
http://dx.doi.org/10.1097/ICB.0000000000001182
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author Desai, Ria
Jampol, Lee M.
author_facet Desai, Ria
Jampol, Lee M.
author_sort Desai, Ria
collection PubMed
description To describe a case of postoperative retinal toxicity following the use of mitomycin C during a routine trabeculectomy. METHODS: Case report of a single patient who underwent complete ophthalmic examination and multimodal imaging, including color fundus photos, optical coherence tomography, fundus autofluorescence, and fluorescein angiography. The study was declared exempt by the Institutional Review Board of Northwestern University. This research followed the tenets of the Declaration of Helsinki. RESULTS: The patient developed profound vision loss and retinal damage during the postoperative course. Posterior segment findings include loss of vascular perfusion, diffuse loss of the outer, then inner, retinal layers, and subsequent total retinal detachment. CONCLUSION: Although mitomycin C is commonly used in glaucoma filtering surgeries, reports of postoperative posterior segment toxicity are rare. The etiology of postoperative toxicity in this case is probable inadvertent intraocular injection of mitomycin C.
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spelling pubmed-101213652023-04-22 RETINAL TOXICITY FOLLOWING PRESUMED INADVERTENT INTRAOCULAR INJECTION OF MITOMYCIN C DURING TRABECULECTOMY Desai, Ria Jampol, Lee M. Retin Cases Brief Rep Case Report To describe a case of postoperative retinal toxicity following the use of mitomycin C during a routine trabeculectomy. METHODS: Case report of a single patient who underwent complete ophthalmic examination and multimodal imaging, including color fundus photos, optical coherence tomography, fundus autofluorescence, and fluorescein angiography. The study was declared exempt by the Institutional Review Board of Northwestern University. This research followed the tenets of the Declaration of Helsinki. RESULTS: The patient developed profound vision loss and retinal damage during the postoperative course. Posterior segment findings include loss of vascular perfusion, diffuse loss of the outer, then inner, retinal layers, and subsequent total retinal detachment. CONCLUSION: Although mitomycin C is commonly used in glaucoma filtering surgeries, reports of postoperative posterior segment toxicity are rare. The etiology of postoperative toxicity in this case is probable inadvertent intraocular injection of mitomycin C. Retinal Cases & Brief Reports 2023-05 2021-07-16 /pmc/articles/PMC10121365/ /pubmed/34293779 http://dx.doi.org/10.1097/ICB.0000000000001182 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Opthalmic Communications Society, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Desai, Ria
Jampol, Lee M.
RETINAL TOXICITY FOLLOWING PRESUMED INADVERTENT INTRAOCULAR INJECTION OF MITOMYCIN C DURING TRABECULECTOMY
title RETINAL TOXICITY FOLLOWING PRESUMED INADVERTENT INTRAOCULAR INJECTION OF MITOMYCIN C DURING TRABECULECTOMY
title_full RETINAL TOXICITY FOLLOWING PRESUMED INADVERTENT INTRAOCULAR INJECTION OF MITOMYCIN C DURING TRABECULECTOMY
title_fullStr RETINAL TOXICITY FOLLOWING PRESUMED INADVERTENT INTRAOCULAR INJECTION OF MITOMYCIN C DURING TRABECULECTOMY
title_full_unstemmed RETINAL TOXICITY FOLLOWING PRESUMED INADVERTENT INTRAOCULAR INJECTION OF MITOMYCIN C DURING TRABECULECTOMY
title_short RETINAL TOXICITY FOLLOWING PRESUMED INADVERTENT INTRAOCULAR INJECTION OF MITOMYCIN C DURING TRABECULECTOMY
title_sort retinal toxicity following presumed inadvertent intraocular injection of mitomycin c during trabeculectomy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121365/
https://www.ncbi.nlm.nih.gov/pubmed/34293779
http://dx.doi.org/10.1097/ICB.0000000000001182
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