UHRF1/UBE2L6/UBR4-mediated ubiquitination regulates EZH2 abundance and thereby melanocytic differentiation phenotypes in melanoma

Cellular heterogeneity in cancer is linked to disease progression and therapy response, although mechanisms regulating distinct cellular states within tumors are not well understood. We identified melanin pigment content as a major source of cellular heterogeneity in melanoma and compared RNAseq dat...

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Detalles Bibliográficos
Autores principales: Kuser-Abali, Gamze, Zhang, Youfang, Szeto, Pacman, Zhao, Peinan, Masoumi-Moghaddam, Samar, Fedele, Clare G., Leece, Isobel, Huang, Cheng, Cheung, Jen G., Ameratunga, Malaka, Noguchi, Fumihito, Andrews, Miles C., Wong, Nicholas C., Schittenhelm, Ralf B., Shackleton, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121471/
https://www.ncbi.nlm.nih.gov/pubmed/36906655
http://dx.doi.org/10.1038/s41388-023-02631-8

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