Downregulation of the Rho GTPase pathway abrogates resistance to ionizing radiation in wild-type p53 glioblastoma by suppressing DNA repair mechanisms

Glioblastoma (GBM), the most common aggressive brain tumor, is characterized by rapid cellular infiltration and is routinely treated with ionizing radiation (IR), but therapeutic resistance inevitably recurs. The actin cytoskeleton of glioblastoma cells provides their high invasiveness, but it remai...

Descripción completa

Detalles Bibliográficos
Autores principales: Magalhaes, Yuli Thamires, Boell, Viktor Kalbermatter, Cardella, Giovanna Duo, Forti, Fabio Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121706/
https://www.ncbi.nlm.nih.gov/pubmed/37085490
http://dx.doi.org/10.1038/s41419-023-05812-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121706/
https://www.ncbi.nlm.nih.gov/pubmed/37085490
http://dx.doi.org/10.1038/s41419-023-05812-1

Ejemplares similares