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Downregulation of the Rho GTPase pathway abrogates resistance to ionizing radiation in wild-type p53 glioblastoma by suppressing DNA repair mechanisms
Glioblastoma (GBM), the most common aggressive brain tumor, is characterized by rapid cellular infiltration and is routinely treated with ionizing radiation (IR), but therapeutic resistance inevitably recurs. The actin cytoskeleton of glioblastoma cells provides their high invasiveness, but it remai...
Autores principales: | Magalhaes, Yuli Thamires, Boell, Viktor Kalbermatter, Cardella, Giovanna Duo, Forti, Fabio Luis |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121706/ https://www.ncbi.nlm.nih.gov/pubmed/37085490 http://dx.doi.org/10.1038/s41419-023-05812-1 |
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