Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers

Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell-specific effect of variants in these genes is not fully understood. Here, we perform single-nucleus RNA-sequencing (snRNA-seq)...

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Detalles Bibliográficos
Autores principales: Brase, Logan, You, Shih-Feng, D’Oliveira Albanus, Ricardo, Del-Aguila, Jorge L., Dai, Yaoyi, Novotny, Brenna C., Soriano-Tarraga, Carolina, Dykstra, Taitea, Fernandez, Maria Victoria, Budde, John P., Bergmann, Kristy, Morris, John C., Bateman, Randall J., Perrin, Richard J., McDade, Eric, Xiong, Chengjie, Goate, Alison M., Farlow, Martin, Sutherland, Greg T., Kipnis, Jonathan, Karch, Celeste M., Benitez, Bruno A., Harari, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121712/
https://www.ncbi.nlm.nih.gov/pubmed/37085492
http://dx.doi.org/10.1038/s41467-023-37437-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121712/
https://www.ncbi.nlm.nih.gov/pubmed/37085492
http://dx.doi.org/10.1038/s41467-023-37437-5

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