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Microbial biomanufacturing for space-exploration—what to take and when to make

As renewed interest in human space-exploration intensifies, a coherent and modernized strategy for mission design and planning has become increasingly crucial. Biotechnology has emerged as a promising approach to increase resilience, flexibility, and efficiency of missions, by virtue of its ability...

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Autores principales: Averesch, Nils J. H., Berliner, Aaron J., Nangle, Shannon N., Zezulka, Spencer, Vengerova, Gretchen L., Ho, Davian, Casale, Cameran A., Lehner, Benjamin A. E., Snyder, Jessica E., Clark, Kevin B., Dartnell, Lewis R., Criddle, Craig S., Arkin, Adam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121718/
https://www.ncbi.nlm.nih.gov/pubmed/37085475
http://dx.doi.org/10.1038/s41467-023-37910-1
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author Averesch, Nils J. H.
Berliner, Aaron J.
Nangle, Shannon N.
Zezulka, Spencer
Vengerova, Gretchen L.
Ho, Davian
Casale, Cameran A.
Lehner, Benjamin A. E.
Snyder, Jessica E.
Clark, Kevin B.
Dartnell, Lewis R.
Criddle, Craig S.
Arkin, Adam P.
author_facet Averesch, Nils J. H.
Berliner, Aaron J.
Nangle, Shannon N.
Zezulka, Spencer
Vengerova, Gretchen L.
Ho, Davian
Casale, Cameran A.
Lehner, Benjamin A. E.
Snyder, Jessica E.
Clark, Kevin B.
Dartnell, Lewis R.
Criddle, Craig S.
Arkin, Adam P.
author_sort Averesch, Nils J. H.
collection PubMed
description As renewed interest in human space-exploration intensifies, a coherent and modernized strategy for mission design and planning has become increasingly crucial. Biotechnology has emerged as a promising approach to increase resilience, flexibility, and efficiency of missions, by virtue of its ability to effectively utilize in situ resources and reclaim resources from waste streams. Here we outline four primary mission-classes on Moon and Mars that drive a staged and accretive biomanufacturing strategy. Each class requires a unique approach to integrate biomanufacturing into the existing mission-architecture and so faces unique challenges in technology development. These challenges stem directly from the resources available in a given mission-class—the degree to which feedstocks are derived from cargo and in situ resources—and the degree to which loop-closure is necessary. As mission duration and distance from Earth increase, the benefits of specialized, sustainable biomanufacturing processes also increase. Consequentially, we define specific design-scenarios and quantify the usefulness of in-space biomanufacturing, to guide techno-economics of space-missions. Especially materials emerged as a potentially pivotal target for biomanufacturing with large impact on up-mass cost. Subsequently, we outline the processes needed for development, testing, and deployment of requisite technologies. As space-related technology development often does, these advancements are likely to have profound implications for the creation of a resilient circular bioeconomy on Earth.
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spelling pubmed-101217182023-04-23 Microbial biomanufacturing for space-exploration—what to take and when to make Averesch, Nils J. H. Berliner, Aaron J. Nangle, Shannon N. Zezulka, Spencer Vengerova, Gretchen L. Ho, Davian Casale, Cameran A. Lehner, Benjamin A. E. Snyder, Jessica E. Clark, Kevin B. Dartnell, Lewis R. Criddle, Craig S. Arkin, Adam P. Nat Commun Perspective As renewed interest in human space-exploration intensifies, a coherent and modernized strategy for mission design and planning has become increasingly crucial. Biotechnology has emerged as a promising approach to increase resilience, flexibility, and efficiency of missions, by virtue of its ability to effectively utilize in situ resources and reclaim resources from waste streams. Here we outline four primary mission-classes on Moon and Mars that drive a staged and accretive biomanufacturing strategy. Each class requires a unique approach to integrate biomanufacturing into the existing mission-architecture and so faces unique challenges in technology development. These challenges stem directly from the resources available in a given mission-class—the degree to which feedstocks are derived from cargo and in situ resources—and the degree to which loop-closure is necessary. As mission duration and distance from Earth increase, the benefits of specialized, sustainable biomanufacturing processes also increase. Consequentially, we define specific design-scenarios and quantify the usefulness of in-space biomanufacturing, to guide techno-economics of space-missions. Especially materials emerged as a potentially pivotal target for biomanufacturing with large impact on up-mass cost. Subsequently, we outline the processes needed for development, testing, and deployment of requisite technologies. As space-related technology development often does, these advancements are likely to have profound implications for the creation of a resilient circular bioeconomy on Earth. Nature Publishing Group UK 2023-04-21 /pmc/articles/PMC10121718/ /pubmed/37085475 http://dx.doi.org/10.1038/s41467-023-37910-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Perspective
Averesch, Nils J. H.
Berliner, Aaron J.
Nangle, Shannon N.
Zezulka, Spencer
Vengerova, Gretchen L.
Ho, Davian
Casale, Cameran A.
Lehner, Benjamin A. E.
Snyder, Jessica E.
Clark, Kevin B.
Dartnell, Lewis R.
Criddle, Craig S.
Arkin, Adam P.
Microbial biomanufacturing for space-exploration—what to take and when to make
title Microbial biomanufacturing for space-exploration—what to take and when to make
title_full Microbial biomanufacturing for space-exploration—what to take and when to make
title_fullStr Microbial biomanufacturing for space-exploration—what to take and when to make
title_full_unstemmed Microbial biomanufacturing for space-exploration—what to take and when to make
title_short Microbial biomanufacturing for space-exploration—what to take and when to make
title_sort microbial biomanufacturing for space-exploration—what to take and when to make
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121718/
https://www.ncbi.nlm.nih.gov/pubmed/37085475
http://dx.doi.org/10.1038/s41467-023-37910-1
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