Cargando…
Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia
All types of dementia, including Alzheimer’s disease, are debilitating neurodegenerative conditions marked by compromised cognitive function for which there are few effective treatments. Positive modulation of hepatocyte growth factor (HGF)/MET, a critical neurotrophic signaling system, may promote...
Autores principales: | Johnston, Jewel L., Reda, Sherif M., Setti, Sharay E., Taylor, Robert W., Berthiaume, Andrée-Anne, Walker, William E., Wu, Wei, Moebius, Hans J., Church, Kevin J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121968/ https://www.ncbi.nlm.nih.gov/pubmed/36538176 http://dx.doi.org/10.1007/s13311-022-01325-5 |
Ejemplares similares
-
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Positive Modulator of HGF/MET, Fosgonimeton, in Healthy Volunteers and Subjects with Alzheimer’s Disease: Randomized, Placebo-Controlled, Double-Blind, Phase I Clinical Trial
por: Hua, Xue, et al.
Publicado: (2022) -
The Case for a Novel Therapeutic Approach to Dementia: Small Molecule Hepatocyte Growth Factor (HGF/MET) Positive Modulators
por: Moebius, Hans J., et al.
Publicado: (2023) -
The procognitive effects of leptin in the brain and their clinical implications
por: Paz-Filho, G, et al.
Publicado: (2010) -
HGF-MET as a breast cancer biomarker
por: Liu, Shuying
Publicado: (2015) -
HGF/c-MET Signaling in Melanocytes and Melanoma
por: Czyz, Malgorzata
Publicado: (2018)