Functional analyses of rare germline BRCA1 variants by transcriptional activation and homologous recombination repair assays

BACKGROUND: Damaging alterations in the BRCA1 gene have been extensively described as one of the main causes of hereditary breast and ovarian cancer (HBOC). BRCA1 alterations can lead to impaired homologous recombination repair (HRR) of double-stranded DNA breaks, a process which involves the RING,...

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Detalles Bibliográficos
Autores principales: Bassi, Nicola, Hovland, Henrikke Nilsen, Rasheed, Kashif, Jarhelle, Elisabeth, Pedersen, Nikara, Mchaina, Eunice Kabanyana, Bakkan, Sara Marie Engelsvold, Iversen, Nina, Høberg-Vetti, Hildegunn, Haukanes, Bjørn Ivar, Knappskog, Per Morten, Aukrust, Ingvild, Ognedal, Elisabet, Van Ghelue, Marijke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122298/
https://www.ncbi.nlm.nih.gov/pubmed/37085799
http://dx.doi.org/10.1186/s12885-023-10790-w

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