The mechanism by which miR-494-3p regulates PGC1-α-mediated inhibition of mitophagy in cardiomyocytes and alleviation of myocardial ischemia—reperfusion injury

OBJECTIVE: The purpose of this study was to explore whether miR-494-3p inhibits the occurrence of mitochondrial autophagy in cardiomyocytes by inhibiting the expression of PGC1-α and to supplement the theoretical basis for the role of autophagy in cardiac injury induced by hypoxia/reperfusion (H/R)....

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Detalles Bibliográficos
Autores principales: Mu, Ninghui, Zhang, Tong, Zhu, Ying, Lu, Bingtuan, Zheng, Qi, Duan, Jinlan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122381/
https://www.ncbi.nlm.nih.gov/pubmed/37085803
http://dx.doi.org/10.1186/s12872-023-03226-7

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