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Virus-induced breath biomarkers: A new perspective to study the metabolic responses of COVID-19 vaccinees
Coronavirus disease 2019 (COVID-19) vaccines can protect people from the infection; however, the action mechanism of vaccine-mediated metabolism remains unclear. Herein, we performed breath tests in COVID-19 vaccinees that revealed metabolic reprogramming induced by protective immune responses. In t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122548/ https://www.ncbi.nlm.nih.gov/pubmed/37116359 http://dx.doi.org/10.1016/j.talanta.2023.124577 |
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author | Cen, Zhengnan Lu, Bingqing Ji, Yongyan Chen, Jian Liu, Yongqian Jiang, Jiakui Li, Xue Li, Xiang |
author_facet | Cen, Zhengnan Lu, Bingqing Ji, Yongyan Chen, Jian Liu, Yongqian Jiang, Jiakui Li, Xue Li, Xiang |
author_sort | Cen, Zhengnan |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) vaccines can protect people from the infection; however, the action mechanism of vaccine-mediated metabolism remains unclear. Herein, we performed breath tests in COVID-19 vaccinees that revealed metabolic reprogramming induced by protective immune responses. In total, 204 breath samples were obtained from COVID-19 vaccinees and non-vaccinated controls, wherein numerous volatile organic compounds (VOCs) were detected by comprehensive two-dimensional gas chromatography and time-of-flight mass spectrometry system. Subsequently, 12 VOCs were selected as biomarkers to construct a signature panel using alveolar gradients and machine learning-based procedure. The signature panel could distinguish vaccinees from control group with a high prediction performance (AUC, 0.9953; accuracy, 94.42%). The metabolic pathways of these biomarkers indicated that the host-pathogen interactions enhanced enzymatic activity and microbial metabolism in the liver, lung, and gut, potentially constituting the dominant action mechanism of vaccine-driven metabolic regulation. Thus, our findings of this study highlight the potential of measuring exhaled VOCs as rapid, non-invasive biomarkers of viral infections. Furthermore, breathomics appears as an alternative for safety evaluation of biological agents and disease diagnosis. |
format | Online Article Text |
id | pubmed-10122548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101225482023-04-24 Virus-induced breath biomarkers: A new perspective to study the metabolic responses of COVID-19 vaccinees Cen, Zhengnan Lu, Bingqing Ji, Yongyan Chen, Jian Liu, Yongqian Jiang, Jiakui Li, Xue Li, Xiang Talanta Article Coronavirus disease 2019 (COVID-19) vaccines can protect people from the infection; however, the action mechanism of vaccine-mediated metabolism remains unclear. Herein, we performed breath tests in COVID-19 vaccinees that revealed metabolic reprogramming induced by protective immune responses. In total, 204 breath samples were obtained from COVID-19 vaccinees and non-vaccinated controls, wherein numerous volatile organic compounds (VOCs) were detected by comprehensive two-dimensional gas chromatography and time-of-flight mass spectrometry system. Subsequently, 12 VOCs were selected as biomarkers to construct a signature panel using alveolar gradients and machine learning-based procedure. The signature panel could distinguish vaccinees from control group with a high prediction performance (AUC, 0.9953; accuracy, 94.42%). The metabolic pathways of these biomarkers indicated that the host-pathogen interactions enhanced enzymatic activity and microbial metabolism in the liver, lung, and gut, potentially constituting the dominant action mechanism of vaccine-driven metabolic regulation. Thus, our findings of this study highlight the potential of measuring exhaled VOCs as rapid, non-invasive biomarkers of viral infections. Furthermore, breathomics appears as an alternative for safety evaluation of biological agents and disease diagnosis. Elsevier B.V. 2023-08-01 2023-04-22 /pmc/articles/PMC10122548/ /pubmed/37116359 http://dx.doi.org/10.1016/j.talanta.2023.124577 Text en © 2023 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Cen, Zhengnan Lu, Bingqing Ji, Yongyan Chen, Jian Liu, Yongqian Jiang, Jiakui Li, Xue Li, Xiang Virus-induced breath biomarkers: A new perspective to study the metabolic responses of COVID-19 vaccinees |
title | Virus-induced breath biomarkers: A new perspective to study the metabolic responses of COVID-19 vaccinees |
title_full | Virus-induced breath biomarkers: A new perspective to study the metabolic responses of COVID-19 vaccinees |
title_fullStr | Virus-induced breath biomarkers: A new perspective to study the metabolic responses of COVID-19 vaccinees |
title_full_unstemmed | Virus-induced breath biomarkers: A new perspective to study the metabolic responses of COVID-19 vaccinees |
title_short | Virus-induced breath biomarkers: A new perspective to study the metabolic responses of COVID-19 vaccinees |
title_sort | virus-induced breath biomarkers: a new perspective to study the metabolic responses of covid-19 vaccinees |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122548/ https://www.ncbi.nlm.nih.gov/pubmed/37116359 http://dx.doi.org/10.1016/j.talanta.2023.124577 |
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