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Excessive disinfection aggravated the environmental prevalence of antimicrobial resistance during COVID-19 pandemic
During COVID-19 pandemic, chemicals from excessive consumption of pharmaceuticals and disinfectants i.e., antibiotics, quaternary ammonium compounds (QACs), and trihalomethanes (THMs), flowed into the urban environment, imposing unprecedented selective pressure to antimicrobial resistance (AMR). To...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122561/ https://www.ncbi.nlm.nih.gov/pubmed/37094669 http://dx.doi.org/10.1016/j.scitotenv.2023.163598 |
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author | Hu, Zhichao Yang, Lihua Liu, Zishu Han, Jian Zhao, Yuxiang Jin, Yihao Sheng, Yaqi Zhu, Lizhong Hu, Baolan |
author_facet | Hu, Zhichao Yang, Lihua Liu, Zishu Han, Jian Zhao, Yuxiang Jin, Yihao Sheng, Yaqi Zhu, Lizhong Hu, Baolan |
author_sort | Hu, Zhichao |
collection | PubMed |
description | During COVID-19 pandemic, chemicals from excessive consumption of pharmaceuticals and disinfectants i.e., antibiotics, quaternary ammonium compounds (QACs), and trihalomethanes (THMs), flowed into the urban environment, imposing unprecedented selective pressure to antimicrobial resistance (AMR). To decipher the obscure character pandemic-related chemicals portrayed in altering environmental AMR, 40 environmental samples covering water and soil matrix from surroundings of Wuhan designated hospitals were collected on March 2020 and June 2020. Chemical concentrations and antibiotic resistance gene (ARG) profiles were revealed by ultra-high-performance liquid chromatography-tandem mass spectrometry and metagenomics. Selective pressure from pandemic-related chemicals ascended by 1.4–5.8 times in March 2020 and then declined to normal level of pre-pandemic period in June 2020. Correspondingly, the relative abundance of ARGs under increasing selective pressure was 20.1 times that under normal selective pressure. Moreover, effect from QACs and THMs in aggravating the prevalence of AMR was elaborated by null model, variation partition and co-occurrence network analyses. Pandemic-related chemicals, of which QACs and THMs respectively displayed close interaction with efflux pump genes and mobile genetic elements, contributed >50 % in shaping ARG profile. QACs bolstered the cross resistance effectuated by qacEΔ1 and cmeB to 3.0 times higher while THMs boosted horizon ARG transfer by 7.9 times for initiating microbial response to oxidative stress. Under ascending selective pressure, qepA encoding quinolone efflux pump and oxa-20 encoding β-lactamases were identified as priority ARGs with potential human health risk. Collectively, this research validated the synergistic effect of QACs and THMs in exacerbating environmental AMR, appealing for the rational usage of disinfectants and the attention for environmental microbes in one-health perspective. |
format | Online Article Text |
id | pubmed-10122561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101225612023-04-24 Excessive disinfection aggravated the environmental prevalence of antimicrobial resistance during COVID-19 pandemic Hu, Zhichao Yang, Lihua Liu, Zishu Han, Jian Zhao, Yuxiang Jin, Yihao Sheng, Yaqi Zhu, Lizhong Hu, Baolan Sci Total Environ Article During COVID-19 pandemic, chemicals from excessive consumption of pharmaceuticals and disinfectants i.e., antibiotics, quaternary ammonium compounds (QACs), and trihalomethanes (THMs), flowed into the urban environment, imposing unprecedented selective pressure to antimicrobial resistance (AMR). To decipher the obscure character pandemic-related chemicals portrayed in altering environmental AMR, 40 environmental samples covering water and soil matrix from surroundings of Wuhan designated hospitals were collected on March 2020 and June 2020. Chemical concentrations and antibiotic resistance gene (ARG) profiles were revealed by ultra-high-performance liquid chromatography-tandem mass spectrometry and metagenomics. Selective pressure from pandemic-related chemicals ascended by 1.4–5.8 times in March 2020 and then declined to normal level of pre-pandemic period in June 2020. Correspondingly, the relative abundance of ARGs under increasing selective pressure was 20.1 times that under normal selective pressure. Moreover, effect from QACs and THMs in aggravating the prevalence of AMR was elaborated by null model, variation partition and co-occurrence network analyses. Pandemic-related chemicals, of which QACs and THMs respectively displayed close interaction with efflux pump genes and mobile genetic elements, contributed >50 % in shaping ARG profile. QACs bolstered the cross resistance effectuated by qacEΔ1 and cmeB to 3.0 times higher while THMs boosted horizon ARG transfer by 7.9 times for initiating microbial response to oxidative stress. Under ascending selective pressure, qepA encoding quinolone efflux pump and oxa-20 encoding β-lactamases were identified as priority ARGs with potential human health risk. Collectively, this research validated the synergistic effect of QACs and THMs in exacerbating environmental AMR, appealing for the rational usage of disinfectants and the attention for environmental microbes in one-health perspective. Elsevier B.V. 2023-07-15 2023-04-23 /pmc/articles/PMC10122561/ /pubmed/37094669 http://dx.doi.org/10.1016/j.scitotenv.2023.163598 Text en © 2023 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Hu, Zhichao Yang, Lihua Liu, Zishu Han, Jian Zhao, Yuxiang Jin, Yihao Sheng, Yaqi Zhu, Lizhong Hu, Baolan Excessive disinfection aggravated the environmental prevalence of antimicrobial resistance during COVID-19 pandemic |
title | Excessive disinfection aggravated the environmental prevalence of antimicrobial resistance during COVID-19 pandemic |
title_full | Excessive disinfection aggravated the environmental prevalence of antimicrobial resistance during COVID-19 pandemic |
title_fullStr | Excessive disinfection aggravated the environmental prevalence of antimicrobial resistance during COVID-19 pandemic |
title_full_unstemmed | Excessive disinfection aggravated the environmental prevalence of antimicrobial resistance during COVID-19 pandemic |
title_short | Excessive disinfection aggravated the environmental prevalence of antimicrobial resistance during COVID-19 pandemic |
title_sort | excessive disinfection aggravated the environmental prevalence of antimicrobial resistance during covid-19 pandemic |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122561/ https://www.ncbi.nlm.nih.gov/pubmed/37094669 http://dx.doi.org/10.1016/j.scitotenv.2023.163598 |
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