The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target

Atopic dermatitis (AD) is a kind of chronic skin disease with inflammatory infiltration, characterized by skin barrier dysfunction, immune response dysregulation, and skin dysbiosis. Thymic stromal lymphopoietin (TSLP) acts as a regulator of immune response, positively associated with AD deteriorati...

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Autores principales: Luo, Jialiang, Zhu, Zhengyumeng, Zhai, Yumeng, Zeng, Junxiang, Li, Lei, Wang, Di, Deng, Fan, Chang, Bo, Zhou, Jia, Sun, Ledong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122597/
https://www.ncbi.nlm.nih.gov/pubmed/37096155
http://dx.doi.org/10.1155/2023/7697699
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author Luo, Jialiang
Zhu, Zhengyumeng
Zhai, Yumeng
Zeng, Junxiang
Li, Lei
Wang, Di
Deng, Fan
Chang, Bo
Zhou, Jia
Sun, Ledong
author_facet Luo, Jialiang
Zhu, Zhengyumeng
Zhai, Yumeng
Zeng, Junxiang
Li, Lei
Wang, Di
Deng, Fan
Chang, Bo
Zhou, Jia
Sun, Ledong
author_sort Luo, Jialiang
collection PubMed
description Atopic dermatitis (AD) is a kind of chronic skin disease with inflammatory infiltration, characterized by skin barrier dysfunction, immune response dysregulation, and skin dysbiosis. Thymic stromal lymphopoietin (TSLP) acts as a regulator of immune response, positively associated with AD deterioration. Mainly secreted by keratinocytes, TSLP interacts with multiple immune cells (including dendritic cells, T cells, and mast cells), following induction of Th2-oriented immune response during the pathogenesis of AD. This article primarily focuses on the TSLP biological function, the relationship between TSLP and different cell populations, and the AD treatments targeting TSLP.
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spelling pubmed-101225972023-04-23 The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target Luo, Jialiang Zhu, Zhengyumeng Zhai, Yumeng Zeng, Junxiang Li, Lei Wang, Di Deng, Fan Chang, Bo Zhou, Jia Sun, Ledong Mediators Inflamm Review Article Atopic dermatitis (AD) is a kind of chronic skin disease with inflammatory infiltration, characterized by skin barrier dysfunction, immune response dysregulation, and skin dysbiosis. Thymic stromal lymphopoietin (TSLP) acts as a regulator of immune response, positively associated with AD deterioration. Mainly secreted by keratinocytes, TSLP interacts with multiple immune cells (including dendritic cells, T cells, and mast cells), following induction of Th2-oriented immune response during the pathogenesis of AD. This article primarily focuses on the TSLP biological function, the relationship between TSLP and different cell populations, and the AD treatments targeting TSLP. Hindawi 2023-04-15 /pmc/articles/PMC10122597/ /pubmed/37096155 http://dx.doi.org/10.1155/2023/7697699 Text en Copyright © 2023 Jialiang Luo et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Luo, Jialiang
Zhu, Zhengyumeng
Zhai, Yumeng
Zeng, Junxiang
Li, Lei
Wang, Di
Deng, Fan
Chang, Bo
Zhou, Jia
Sun, Ledong
The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target
title The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target
title_full The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target
title_fullStr The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target
title_full_unstemmed The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target
title_short The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target
title_sort role of tslp in atopic dermatitis: from pathogenetic molecule to therapeutical target
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122597/
https://www.ncbi.nlm.nih.gov/pubmed/37096155
http://dx.doi.org/10.1155/2023/7697699
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