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Transcription factor binding site orientation and order are major drivers of gene regulatory activity

The gene regulatory code and grammar remain largely unknown, precluding our ability to link phenotype to genotype in regulatory sequences. Here, using a massively parallel reporter assay (MPRA) of 209,440 sequences, we examine all possible pair and triplet combinations, permutations and orientations...

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Detalles Bibliográficos
Autores principales:	Georgakopoulos-Soares, Ilias, Deng, Chengyu, Agarwal, Vikram, Chan, Candace S. Y., Zhao, Jingjing, Inoue, Fumitaka, Ahituv, Nadav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122648/ https://www.ncbi.nlm.nih.gov/pubmed/37087538 http://dx.doi.org/10.1038/s41467-023-37960-5

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